TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis. - Wikidata - awgldk - TriplyDB

TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.

TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.

http://www.wikidata.org/entity/Q37066493

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Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss Targeting neuroinflammation in Alzheimer's disease Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions.Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia.Podosome organization drives osteoclast-mediated bone resorption.Integrative analysis of multiple diverse omics datasets by sparse group multitask regression.TREM-2 promotes macrophage survival and lung disease after respiratory viral infection Gene expression changes in human mesenchymal stem cells from patients with osteoporosis.Relevance of Wnt signaling for osteoanabolic therapy.Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice.The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective.TREM2 regulates microglial cell activation in response to demyelination in vivo.The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages.Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.HDAC7 inhibits osteoclastogenesis by reversing RANKL-triggered β-catenin switch.Osteoclasts-Key Players in Skeletal Health and Disease.Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease.CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells.Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.Osteoimmunology: the expanding role of immunoreceptors in osteoclasts and bone remodeling Review: The genetics of Alzheimer's disease; putting flesh on the bones.Screening for potential genes associated with bone overgrowth after mid-shaft femur fracture in a rat model.Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update.TREM2 in Neurodegenerative Diseases.The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases TREM2-Ligand Interactions in Health and Disease.Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases.TREM2 sustains microglial expansion during aging and response to demyelination.Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin.TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.Discovery of novel frizzled-7 inhibitors by targeting the receptor's transmembrane domain.MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis.Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes.

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TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.

http://www.wikidata.org/entity/Q37066493

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 06 February 2012

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

TREM2 and β-catenin regulate b ...... he rate of osteoclastogenesis.

@en

TREM2 and β-catenin regulate b ...... he rate of osteoclastogenesis.

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type

label

TREM2 and β-catenin regulate b ...... he rate of osteoclastogenesis.

@en

TREM2 and β-catenin regulate b ...... he rate of osteoclastogenesis.

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prefLabel

TREM2 and β-catenin regulate b ...... he rate of osteoclastogenesis.

@en

TREM2 and β-catenin regulate b ...... he rate of osteoclastogenesis.

@nl

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JIMMUNOL.1102836

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Journal of Immunology

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TREM2 and β-catenin regulate b ...... he rate of osteoclastogenesis.

@en

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Angela Colucci

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F Patrick Ross

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Haibo Zhao

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Hiroshi Takayanagi

http://www.w3.org/2001/XMLSchema#string

Karel Otero

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Roberta Faccio

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Steve L Teitelbaum

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P2860

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features

Impaired differentiation of osteoclasts in TREM-2-deficient individuals

Osteoclasts: what do they do and how do they do it?

Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12

Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization.

Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

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2612-2621

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scholarly article

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10.4049/JIMMUNOL.1102836

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6

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188

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Susan Gilfillan

Masahiro Shinohara

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2012-02-06T00:00:00Z

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221812461

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22312126

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3732181

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