TREM2 sustains microglial expansion during aging and response to demyelination. - Wikidata - awgldk - TriplyDB

TREM2 sustains microglial expansion during aging and response to demyelination.

TREM2 sustains microglial expansion during aging and response to demyelination.

http://www.wikidata.org/entity/Q41920489

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Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair TREM2 in CNS homeostasis and neurodegenerative disease Phagocytosis of apoptotic cells in homeostasis Immune Surveillance of the CNS following Infection and Injury Central Nervous System: (Immunological) Ivory Tower or Not?Regulation of microglial survival and proliferation in health and diseases.Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD).Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).Microglial malfunction: the third rail in the development of Alzheimer's disease.The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis.Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury.The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation TREM2 in Neurodegenerative Diseases.The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis.Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood.TREM2-Ligand Interactions in Health and Disease.The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway Heterozygote galactocerebrosidase (GALC) mutants have reduced remyelination and impaired myelin debris clearance following demyelinating injury.Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation.Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia.Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases.Microglia: Housekeeper of the Central Nervous System.Myelin as an inflammatory mediator: Myelin interactions with complement, macrophages, and microglia in spinal cord injury.Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages.A mouse model for testing remyelinating therapies.The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Age-related myelin degradation burdens the clearance function of microglia during aging.Effect of glial cells on remyelination after spinal cord injury.Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease.Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia.

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TREM2 sustains microglial expansion during aging and response to demyelination.

http://www.wikidata.org/entity/Q41920489

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

@zh-cn

name

TREM2 sustains microglial expansion during aging and response to demyelination.

@en

type

label

TREM2 sustains microglial expansion during aging and response to demyelination.

@en

prefLabel

TREM2 sustains microglial expansion during aging and response to demyelination.

@en

P1433

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P1433

Journal of Clinical Investigation

P1476

TREM2 sustains microglial expansion during aging and response to demyelination.

@en

P2093

Elena Fontana

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Michelle L Robinette

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Yaming Wang

http://www.w3.org/2001/XMLSchema#string

Yoshinori Yamanishi

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P2860

TREM2 Variants in Alzheimer's Disease

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming

Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation

Identification of a unique TGF-β-dependent molecular and functional signature in microglia

Pattern recognition by TREM-2: binding of anionic ligands

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2161-2170

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scholarly article

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10.1172/JCI77983

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5

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125

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Susan Gilfillan

Pietro Luigi Poliani

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2015-04-20T00:00:00Z

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25893602

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4463196

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