Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
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Role of Nrf2 in oxidative stress and toxicityCritical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activationDisruption of Nrf2 synergizes with high glucose to cause heightened myocardial oxidative stress and severe cardiomyopathy in diabetic miceNew synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stressDNA Damage: A Main Determinant of Vascular AgingCharacterization and redox mechanism of asthma in the elderlyStructure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDONrf2 Is an Attractive Therapeutic Target for Retinal DiseasesNuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung FibrosisStress-activated cap'n'collar transcription factors in aging and human diseaseNrf2 expression is increased in peripheral blood mononuclear cells derived from mild-moderate ex-smoker COPD patients with persistent oxidative stressThe complexity of the Nrf2 pathway: beyond the antioxidant responseNrf2 regulates chronic lung inflammation and B-cell responses to nontypeable Haemophilus influenzaeCytoprotection "gone astray": Nrf2 and its role in cancerLack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled TrialReactive oxygen species in inflammation and tissue injuryNrf2 is required for normal postnatal bone acquisition in miceEffect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human immortalized BBB endothelial cell lineRtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysemaMechanism of chemical activation of Nrf2Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activationRNAi Screen for NRF2 Inducers Identifies Targets That Rescue Primary Lung Epithelial Cells from Cigarette Smoke Induced Radical StressOxidative Stress in COPD: Sources, Markers, and Potential MechanismsNRF2 plays a protective role in diabetic retinopathy in miceNrf2 regulates gene-environment interactions in an animal model of intrauterine inflammation: Implications for preterm birth and prematurityNADPH oxidase limits innate immune responses in the lungs in miceHeightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.Nrf2: friend or foe for chemoprevention?Nrf2 deficiency exaggerates doxorubicin-induced cardiotoxicity and cardiac dysfunction.Source of biomass cooking fuel determines pulmonary response to household air pollution.Noblesse oblige: NRF2 functions in the airways.Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.Macrophage migration inhibitory factor is a novel determinant of cigarette smoke-induced lung damage.The saponins: polar isoprenoids with important and diverse biological activities.Proteomic analysis shows synthetic oleanane triterpenoid binds to mTORHuman alveolar epithelial cell injury induced by cigarette smokeExtracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM.Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis.An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1
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P2860
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 22 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
Targeting Nrf2 with the triter ...... nd cardiac dysfunction in mice
@en
Targeting Nrf2 with the triter ...... d cardiac dysfunction in mice.
@nl
type
label
Targeting Nrf2 with the triter ...... nd cardiac dysfunction in mice
@en
Targeting Nrf2 with the triter ...... d cardiac dysfunction in mice.
@nl
prefLabel
Targeting Nrf2 with the triter ...... nd cardiac dysfunction in mice
@en
Targeting Nrf2 with the triter ...... d cardiac dysfunction in mice.
@nl
P2093
P2860
P356
P1476
Targeting Nrf2 with the triter ...... nd cardiac dysfunction in mice
@en
P2093
David J Blake
Deepti Malhotra
Djahida Bedja
Hazim El-Haddad
Hunter C Champion
Kathleen L Gabrielson
Masayuki Yamamoto
Melinda S Yates
Michael B Sporn
Ponvijay Kombairaju
P2860
P304
P356
10.1073/PNAS.0804333106
P407
P577
2008-12-22T00:00:00Z