p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 mem
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SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cellsSignal regulatory protein alpha (SIRPalpha)/CD47 interaction and functionP66Shc signals to age.p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation.Insulin-like growth factor 1 physiology: lessons from mouse models.AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation.PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival.Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells.The Shc locus regulates insulin signaling and adiposity in mammalsThe adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.Mitochondrial longevity pathwaysSuppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cellsHyperglycemia enhances IGF-I-stimulated Src activation via increasing Nox4-derived reactive oxygen species in a PKCζ-dependent manner in vascular smooth muscle cells.Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling.Hyperglycemia stimulates p62/PKCζ interaction, which mediates NF-κB activation, increased Nox4 expression, and inflammatory cytokine activation in vascular smooth muscleIGF-I and IGFBP-2 Stimulate AMPK Activation and Autophagy, Which Are Required for Osteoblast DifferentiationIron modulates cell survival in a Ras- and MAPK-dependent manner in ovarian cellsRecruitment of Nox4 to a plasma membrane scaffold is required for localized reactive oxygen species generation and sustained Src activation in response to insulin-like growth factor-I.The heparin-binding domains of IGFBP-2 mediate its inhibitory effect on preadipocyte differentiation and fat development in male mice.Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells.IGFBP-2 directly stimulates osteoblast differentiation.The adaptor proteins p66Shc and Grb2 regulate the activation of the GTPases ARF1 and ARF6 in invasive breast cancer cells.Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity.Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development.New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases.Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptorAcute Ethanol Increases IGF-I-Induced Phosphorylation of ERKs by Enhancing Recruitment of p52-Shc to the Grb2/Shc Complex.Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.The role of the ShcD and RET interaction in neuroblastoma survival and migration.
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p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 mem
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
p66shc negatively regulates in ...... r receptor-bound protein-2 mem
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p66shc negatively regulates in ...... r receptor-bound protein-2 mem
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p66shc negatively regulates in ...... r receptor-bound protein-2 mem
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p66shc negatively regulates in ...... r receptor-bound protein-2 mem
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p66shc negatively regulates in ...... r receptor-bound protein-2 mem
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p66shc negatively regulates in ...... r receptor-bound protein-2 mem
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P2093
P2860
P356
P1476
p66shc negatively regulates in ...... r receptor-bound protein-2 mem
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David R Clemmons
Xinchun Shen
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P304
P356
10.1210/ME.2008-0079
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2008-07-07T00:00:00Z