ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.
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Role of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancerGemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancerHyperthermia inhibits recombination repair of gemcitabine-stalled replication forks.Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition.The human immunodeficiency virus protease inhibitor ritonavir inhibits lung cancer cells, in part, by inhibition of survivin.Ovarian cancer: in search of better marker systems based on DNA repair defectsPhase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias.Plk1 inhibition enhances the efficacy of gemcitabine in human pancreatic cancer.Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics.Prospects for the Use of ATR Inhibitors to Treat Cancer.P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance.Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs.Overexpression of karyopherin-α2 in cholangiocarcinoma correlates with poor prognosis and gemcitabine sensitivity via nuclear translocation of DNA repair proteins.INPP4B and RAD50 have an interactive effect on survival after breast cancer.MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells.Superresolution imaging of individual replication forks reveals unexpected prodrug resistance mechanism.
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ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
ATM and the Mre11-Rad50-Nbs1 c ...... contribute to drug resistance.
@en
ATM and the Mre11-Rad50-Nbs1 c ...... contribute to drug resistance.
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type
label
ATM and the Mre11-Rad50-Nbs1 c ...... contribute to drug resistance.
@en
ATM and the Mre11-Rad50-Nbs1 c ...... contribute to drug resistance.
@nl
prefLabel
ATM and the Mre11-Rad50-Nbs1 c ...... contribute to drug resistance.
@en
ATM and the Mre11-Rad50-Nbs1 c ...... contribute to drug resistance.
@nl
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ATM and the Mre11-Rad50-Nbs1 c ...... contribute to drug resistance.
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Brett Ewald
Deepa Sampath
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10.1158/0008-5472.CAN-08-0971
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P577
2008-10-01T00:00:00Z