The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
about
P1343
The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancersATM-dependent phosphorylation of nibrin in response to radiation exposureThe ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesisMre11 complex and DNA replication: linkage to E2F and sites of DNA synthesisExome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signalingDNA end resection by CtIP and exonuclease 1 prevents genomic instabilitySenataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damageMRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repairRAD50 and NBS1 form a stable complex functional in DNA binding and tetheringA genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegiaAutosomal recessive cerebellar ataxia with oculomotor apraxia (ataxia-telangiectasia-like syndrome) is linked to chromosome 9q34Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localizationHuman Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpointC. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G(2) DNA damage checkpointChk2 phosphorylation of BRCA1 regulates DNA double-strand break repairBASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structuresMolecular pathology of ataxia telangiectasiaBiochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2Homologous Recombination and Its Role in CarcinogenesisMre11 assembles linear DNA fragments into DNA damage signaling complexesConnecting Malfunctioning Glial Cells and Brain Degenerative DisordersPhenotypes and genotypes of the chromosomal instability syndromesDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorNucleases in homologous recombination as targets for cancer therapyChemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promisingTelomere shortening in human diseasesThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesPathogenesis of ataxia-telangiectasia: the next generation of ATM functionsR-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxiasThe crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partneringCrystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA RepairMre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break RepairNbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and RepairThe Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break RepairATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complexMre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repairDNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease ActivitiesStructure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingEffect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro
P2860
Q21260410-613C7039-5EB2-4839-8970-5FCDBBC13965Q22254062-19EAF715-048E-4D18-8193-DC7B0F18A332Q24291114-4DDF6E35-23BF-4577-9671-CA9CD30742BDQ24291532-F08633F1-D30F-4FC5-9647-510A0B688A6BQ24294774-BEBE45EC-1EE0-4D27-9A71-842B6B76824AQ24305549-247F1787-6061-4F64-A814-9754CE9EB8C5Q24309516-6FD597E2-6F34-4B1D-9A4A-3600576BB670Q24315682-4CBABC19-B18E-4955-A0E7-FC9E159D2FFBQ24317537-E2B3F5F4-967E-4C76-9ED2-125F409DC278Q24338151-965C5714-44B3-433F-8189-18FA821DC5CFQ24534674-1BAD50B5-588A-4BD5-BEB3-30C511B54B38Q24550990-A7CECA2A-29BE-4B09-A2D1-F6F7692B2559Q24562757-2BD87CFB-60C3-4EDB-AD2D-DDFFE4848CEDQ24602472-DCA074EA-7B5F-4B7B-B999-73F48C6EAB16Q24603375-395FF36F-A621-4B8E-8132-68EBDD4683B4Q24606873-D393F5C9-6346-46CB-A0B0-39628BC8AF99Q24672363-7AFF4275-B655-4CB8-A3B5-45147079A914Q24677826-1B337540-A031-4155-BA02-42CD99F2B991Q24793756-FA33B6DB-C6D8-47FC-8285-56190009F388Q24796676-6C7D6C9B-7EB5-478B-B999-4708371F8DADQ26744443-FE8676FD-5D6C-4A48-B7B0-8170383A6306Q26749099-7EB7E017-12DC-4DD0-8D68-16CCC3842ED5Q26776513-D371275E-F0BE-4DA9-A116-A3A085DFA540Q26777987-CDB2A798-23BF-4ACF-85F9-0072B692F788Q26822478-4449248D-4150-4459-BA97-DA6C91BED90AQ26863501-0CD1CF8A-36A4-4429-82CD-A5A8A92B8DBDQ27004080-698CE6D8-51A8-4581-90A9-2A77E118DE1BQ27010421-0F20D3FE-3604-4370-AE7B-75EB7311A509Q27025786-DC00CED0-985A-49F9-A856-86EB6AD7103BQ27318630-7DF55744-B24A-4651-A5AB-E74F9354EFA4Q27643804-750BB0A4-F0B4-4D68-A6A1-706981CA00D0Q27644430-6B11F9B3-3D82-43E3-87F2-A6FF7FBC7A3DQ27652502-A4B7ADF9-C5CE-4A8F-B3F8-074615879E4AQ27657670-F3F1C3C7-0327-4EA2-87F9-8A9075587DE8Q27667404-44197508-FA04-47ED-8269-2780EEF390EEQ27674381-8C09B2B6-41CC-47F0-93F8-EF6DC6BCC657Q27674627-13C3A7D2-1261-46D2-B0C8-6EC69FBD54A3Q27680811-491A8FD3-8E30-4A1A-BFCE-A539F711EE0DQ27681202-FEB6EDC6-3CA8-489B-A3F9-1F31498AB222Q27853018-605F6D33-472C-4C6B-9502-67E404755673
P2860
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
description
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im Dezember 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/12/10)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/12/10)
@nl
наукова стаття, опублікована в грудні 1999
@uk
научни чланак (објављен 1999/12/10)
@sr
name
The DNA double-strand break re ...... a-telangiectasia-like disorder
@ast
The DNA double-strand break re ...... a-telangiectasia-like disorder
@en
The DNA double-strand break re ...... a-telangiectasia-like disorder
@nl
type
label
The DNA double-strand break re ...... a-telangiectasia-like disorder
@ast
The DNA double-strand break re ...... a-telangiectasia-like disorder
@en
The DNA double-strand break re ...... a-telangiectasia-like disorder
@nl
prefLabel
The DNA double-strand break re ...... a-telangiectasia-like disorder
@ast
The DNA double-strand break re ...... a-telangiectasia-like disorder
@en
The DNA double-strand break re ...... a-telangiectasia-like disorder
@nl
P2093
P3181
P1433
P1476
The DNA double-strand break re ...... a-telangiectasia-like disorder
@en
P2093
A M Taylor
D A Bressan
J H Petrini
M I Kaplan
N G Jaspers
P304
P3181
P356
10.1016/S0092-8674(00)81547-0
P407
P577
1999-12-01T00:00:00Z