New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.
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Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channelsHyperpolarization-activated current, If, in mathematical models of rabbit sinoatrial node pacemaker cellsAdvances in the management of heart failure: the role of ivabradineAge-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca(2+) signalingStochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells.From two competing oscillators to one coupled-clock pacemaker cell systemPotential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firingImpaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease.Modern perspectives on numerical modeling of cardiac pacemaker cellRyR-NCX-SERCA local cross-talk ensures pacemaker cell function at rest and during the fight-or-flight reflex.Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells.The fractal-like complexity of heart rate variability beyond neurotransmitters and autonomic receptors: signaling intrinsic to sinoatrial node pacemaker cellsThe end effector of circadian heart rate variation: the sinoatrial node pacemaker cell.Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells.Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²⁺ cycling dynamics.The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell MechanismsPacemaker gene mutations, bradycardia, arrhythmias and the coupled clock theory.Numerical Modeling Calcium and CaMKII Effects in the SA Node.Spontaneous inward currents reflecting oscillatory activation of Na⁺/Ca²⁺ exchangers in human embryonic stem cell-derived cardiomyocytes.Computational analysis of the human sinus node action potential: model development and effects of mutations.Dynamics of PKA phosphorylation and gain of function in cardiac pacemaker cells: a computational model analysis.Contributions of cardiac "funny" (f) channels and sarcoplasmic reticulum Ca2+ in regulating beating rate of mouse and guinea pig sinoatrial nodeCa(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function.Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cellsAge-related pacemaker deterioration is due to impaired intracellular and membrane mechanisms: Insights from numerical modeling.Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials.
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New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 May 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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New evidence for coupled clock ...... of intracellular Ca²⁺ cycling.
@en
New evidence for coupled clock ...... of intracellular Ca²⁺ cycling.
@nl
type
label
New evidence for coupled clock ...... of intracellular Ca²⁺ cycling.
@en
New evidence for coupled clock ...... of intracellular Ca²⁺ cycling.
@nl
prefLabel
New evidence for coupled clock ...... of intracellular Ca²⁺ cycling.
@en
New evidence for coupled clock ...... of intracellular Ca²⁺ cycling.
@nl
P2093
P2860
P50
P1476
New evidence for coupled clock ...... of intracellular Ca²⁺ cycling
@en
P2093
Bruce D Ziman
Harold A Spurgeon
Syevda Sirenko
P2860
P356
10.1016/J.YJMCC.2013.04.026
P577
2013-05-05T00:00:00Z