Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49 - Wikidata - awgldk - TriplyDB

Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49

Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49

http://www.wikidata.org/entity/Q24679415

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Ivabradine as adjuvant treatment for chronic heart failure Ivabradine as adjuvant treatment for chronic heart failure Ivabradine -- the first selective sinus node I(f) channel inhibitor in the treatment of stable angina.Recent advances in treatment of heart failure Ivabradine, coronary artery disease, and heart failure: beyond rhythm control Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven?Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina Haemodynamic effects of the bacterial quorum sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, in conscious, normal and endotoxaemic rats Reducing elevated heart rate in patients with multiple organ dysfunction syndrome by the I (f) (funny channel current) inhibitor ivabradine : MODI (f)Y trial.Risk-benefit assessment of ivabradine in the treatment of chronic heart failure Exercise training reduces resting heart rate via downregulation of the funny channel HCN4 Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells.Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.Morbidity and mortality in cardiovascular disorders: impact of reduced heart rate.Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression.Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells.I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities.Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice.Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker.Effects of the two enantiomers, S-16257-2 and S-16260-2, of a new bradycardic agent on guinea-pig isolated cardiac preparations.The Effect of Ivabradine on the Heart Rate and Sympathovagal Balance in Postural Tachycardia Syndrome Patients Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity.hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.Drug insight: If inhibitors as specific heart-rate-reducing agents.Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine Preclinical results with I(f) current inhibition by ivabradine.I f inhibition with ivabradine : electrophysiological effects and safety.Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents.New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.Genesis and regulation of the heart automaticity.Ivabradine: beyond heart rate control.Review of the If selective channel inhibitor ivabradine in the treatment of chronic stable angina.Rate control with ivabradine: angina pectoris and beyond.Innovation in coronary artery disease and heart failure: clinical benefits of pure heart rate reduction with ivabradine.Selective and specific I(f) inhibition with ivabradine: new perspectives for the treatment of cardiovascular disease.Angina pectoris: current therapy and future treatment options.Funny and late: targeting currents governing heart rate in atrial fibrillation.An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation.Ivabradine for the treatment of chronic heart failure.

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P2860

Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49

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1994 nî lūn-bûn

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J.1476-5381.1994.TB13025.X

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British Journal of Pharmacology

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Electrophysiological effects o ...... ions: comparison with UL-FS 49

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C Cambarrat

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C Thollon

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J F Prost

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P2860

Investigations into the bradycardic effects of UL-FS 49 (1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(3,4-dimethoxyphenyl)ethyl] methylimino]propyl]-2H-3-benzazepin-2-on-hydrochloride) in isolated guinea pig atria

Role of potassium channels in cycle length dependent regulation of action potential duration in mammalian cardiac Purkinje and ventricular muscle fibres.

Adverse cardiovascular effects of anti-arrhythmia drugs. Part I: Proarrhythmic effects.

Comparison of the haemodynamic effects of the selective bradycardic agent UL-FS 49, with those of propranolol during treadmill exercise in dogs.

Cellular electrophysiologic mechanisms of cardiac arrhythmias.

Pharmacology of acute effort angina.

Influence of drug therapy on the ischemic response to acute coronary occlusion in man: supply-side economics.

Specific bradycardic agents--a novel pharmacological class?

Oxygen consumption of the heart. Newer concepts of its multifactoral determination.

Cardiac pacemaking in the sinoatrial node.

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37-42

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1

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15165907

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8032660

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electrophysiology

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1910295

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