Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products.
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Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem"Alkaloids from marine invertebrates as important leads for anticancer drugs discovery and developmentCoalition of Biology and Chemistry for Ameliorating Antimicrobial Drug Discovery.Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds.Guiding principles for natural product drug discovery.Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility.Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection.Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40.Commentary: Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenalPrecursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocketA polyketide macrolactone synthase from the filamentous fungus Gibberella zeaeExpanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domainCombined chemical and biosynthetic route to access a new apoptolidin congenerGatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.The structural diversity of acidic lipopeptide antibiotics.Indole diterpene alkaloids as novel inhibitors of the Wnt/β-catenin pathway in breast cancer cells.Fungal cyclooligomer depsipeptides: from classical biochemistry to combinatorial biosynthesis.Hutchinson's legacy: keeping on polyketide biosynthesis.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.Synthetic biological approaches to natural product biosynthesis.The generation of "unnatural" products: synthetic biology meets synthetic chemistry.Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity.Industrial natural product chemistry for drug discovery and development.Steps towards the synthetic biology of polyketide biosynthesis.Design and synthesis of analogues of natural products.Preparation of thermocleavable conjugates based on ansamitocin and superparamagnetic nanostructured particles by a chemobiosynthetic approach.Bioactive derivatives of isopropylstilbene from mutasynthesis and chemical synthesis.Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification.Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.Preparation of new alkyne-modified ansamitocins by mutasynthesis.Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations.Precursor-directed biosynthesis of curcumin analogs in Escherichia coli.Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP.Engineered polyketides: Synergy between protein and host level engineering.In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines.Precursor-directed combinatorial biosynthesis of cephalosporin analogue by endolithic actinobacterium Streptomyces sp. AL51 by utilizing thiophene derivative.Synthetic diversification of natural products: semi-synthesis and evaluation of triazole jadomycinsPrecursor-Directed Biosynthesis of Polyketide and Nonribosomal Peptide Natural ProductsHigh-Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and Polyketide Analysis
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P2860
Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 04 September 2007
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mutasynthesis, chemobiosynthes ...... diversifying natural products.
@en
Mutasynthesis, chemobiosynthes ...... diversifying natural products.
@nl
type
label
Mutasynthesis, chemobiosynthes ...... diversifying natural products.
@en
Mutasynthesis, chemobiosynthes ...... diversifying natural products.
@nl
prefLabel
Mutasynthesis, chemobiosynthes ...... diversifying natural products.
@en
Mutasynthesis, chemobiosynthes ...... diversifying natural products.
@nl
P2860
P356
P1476
Mutasynthesis, chemobiosynthes ...... diversifying natural products.
@en
P2093
Jonathan Kennedy
P2860
P356
10.1039/B707678A
P577
2007-09-04T00:00:00Z