Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein
about
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-ILack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret modelThe structural basis for cap binding by influenza virus polymerase subunit PB2Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicingChemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus InhibitionApoptosis, cytokine and chemokine induction by non-structural 1 (NS1) proteins encoded by different influenza subtypesAn influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo.Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis.Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles.The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication.Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication.Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responsesMutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs.Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence.The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription.Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation.Amino acid substitutions in PB1 of avian influenza viruses influence pathogenicity and transmissibility in chickens.Intracellular distribution of NS1 correlates with the infectivity and interferon antagonism of an avian influenza virus (H7N1).Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response.The RNA-binding domain of influenzavirus non-structural protein-1 cooperatively binds to virus-specific RNA sequences in a structure-dependent mannerVaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccineStrong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene.Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes.Generation of replication-proficient influenza virus NS1 point mutants with interferon-hyperinducer phenotype.Identification of RNA helicase A as a cellular factor that interacts with influenza A virus NS1 protein and its role in the virus life cycleAttenuated influenza virus construct with enhanced hemagglutinin protein expressionA new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity.SUMOylation affects the interferon blocking activity of the influenza A nonstructural protein NS1 without affecting its stability or cellular localization.Influenza a virus polymerase is an integral component of the CPSF30-NS1A protein complex in infected cells.Evidence for a novel gene associated with human influenza A viruses.The influenza virus RNA synthesis machine: advances in its structure and function.Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation?Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA.Influenza A Virus NS1 Protein Promotes Efficient Nuclear Export of Unspliced Viral M1 mRNA.Influenza Virus and Chromatin: Role of the CHD1 Chromatin Remodeler in the Virus Life Cycle.The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication.An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response.CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infection.The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes.
P2860
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P2860
Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Defective RNA replication and ...... leted forms of the NS1 protein
@en
Defective RNA replication and ...... eted forms of the NS1 protein.
@nl
type
label
Defective RNA replication and ...... leted forms of the NS1 protein
@en
Defective RNA replication and ...... eted forms of the NS1 protein.
@nl
prefLabel
Defective RNA replication and ...... leted forms of the NS1 protein
@en
Defective RNA replication and ...... eted forms of the NS1 protein.
@nl
P2093
P2860
P1433
P1476
Defective RNA replication and ...... leted forms of the NS1 protein
@en
P2093
Agustín Portela
Amelia Nieto
Ana M Falcón
Juan Ortín
Paulino Gómez
Rosa M Marión
Thomas Zürcher
P2860
P304
P356
10.1128/JVI.78.8.3880-3888.2004
P407
P577
2004-04-01T00:00:00Z