Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein - Wikidata - awgldk - TriplyDB

Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein

Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein

http://www.wikidata.org/entity/Q37093452

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Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model The structural basis for cap binding by influenza virus polymerase subunit PB2 Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus Inhibition Apoptosis, cytokine and chemokine induction by non-structural 1 (NS1) proteins encoded by different influenza subtypes An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo.Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis.Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles.The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication.Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication.Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responses Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs.Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence.The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription.Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation.Amino acid substitutions in PB1 of avian influenza viruses influence pathogenicity and transmissibility in chickens.Intracellular distribution of NS1 correlates with the infectivity and interferon antagonism of an avian influenza virus (H7N1).Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response.The RNA-binding domain of influenzavirus non-structural protein-1 cooperatively binds to virus-specific RNA sequences in a structure-dependent manner Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene.Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes.Generation of replication-proficient influenza virus NS1 point mutants with interferon-hyperinducer phenotype.Identification of RNA helicase A as a cellular factor that interacts with influenza A virus NS1 protein and its role in the virus life cycle Attenuated influenza virus construct with enhanced hemagglutinin protein expression A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity.SUMOylation affects the interferon blocking activity of the influenza A nonstructural protein NS1 without affecting its stability or cellular localization.Influenza a virus polymerase is an integral component of the CPSF30-NS1A protein complex in infected cells.Evidence for a novel gene associated with human influenza A viruses.The influenza virus RNA synthesis machine: advances in its structure and function.Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation?Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA.Influenza A Virus NS1 Protein Promotes Efficient Nuclear Export of Unspliced Viral M1 mRNA.Influenza Virus and Chromatin: Role of the CHD1 Chromatin Remodeler in the Virus Life Cycle.The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication.An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response.CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infection.The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes.

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Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein

http://www.wikidata.org/entity/Q37093452

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on April 2004

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Defective RNA replication and ...... leted forms of the NS1 protein

@en

Defective RNA replication and ...... eted forms of the NS1 protein.

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type

label

Defective RNA replication and ...... leted forms of the NS1 protein

@en

Defective RNA replication and ...... eted forms of the NS1 protein.

@nl

prefLabel

Defective RNA replication and ...... leted forms of the NS1 protein

@en

Defective RNA replication and ...... eted forms of the NS1 protein.

@nl

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JVI.78.8.3880-3888.2004

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Journal of Virology

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Defective RNA replication and ...... leted forms of the NS1 protein

@en

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Agustín Portela

http://www.w3.org/2001/XMLSchema#string

Amelia Nieto

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Ana M Falcón

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Juan Ortín

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Paulino Gómez

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Rosa M Marión

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Thomas Zürcher

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P2860

Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro

A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system

Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells

Selective nuclear export of viral mRNAs in influenza-virus-infected cells.

Molecular assembly of influenza virus: association of the NS2 protein with virion matrix.

SV40-transformed simian cells support the replication of early SV40 mutants

Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication.

Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS

Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport

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3880-3888

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scholarly article

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10.1128/JVI.78.8.3880-3888.2004

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2004-04-01T00:00:00Z

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15047804

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374278

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