Mechanism of insolubilization by a single-point mutation in alphaA-crystallin linked with hereditary human cataracts.
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In vivo substrates of the lens molecular chaperones αA-crystallin and αB-crystallinAlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice.The small heat-shock protein HspL is a VirB8 chaperone promoting type IV secretion-mediated DNA transferAltered chaperone-like activity of alpha-crystallins promotes cataractogenesis.A knock-in mouse model for the R120G mutation of αB-crystallin recapitulates human hereditary myopathy and cataracts.Different alpha crystallin expression in human age-related and congenital cataract lens epithelium.Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins αA- and αB-crystallin.p62 expression and autophagy in αB-crystallin R120G mutant knock-in mouse model of hereditary cataract.Lens aging: effects of crystallins.In vivo lens deficiency of the R49C alphaA-crystallin mutant.Quantitative biometric phenotype analysis in mouse lenses.Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataractsOligomerization with wt αA- and αB-crystallins reduces proteasome-mediated degradation of C-terminally truncated αA-crystallin.Activation of the unfolded protein response by a cataract-associated αA-crystallin mutation.Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.
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P2860
Mechanism of insolubilization by a single-point mutation in alphaA-crystallin linked with hereditary human cataracts.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 August 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mechanism of insolubilization ...... th hereditary human cataracts.
@en
Mechanism of insolubilization ...... th hereditary human cataracts.
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type
label
Mechanism of insolubilization ...... th hereditary human cataracts.
@en
Mechanism of insolubilization ...... th hereditary human cataracts.
@nl
prefLabel
Mechanism of insolubilization ...... th hereditary human cataracts.
@en
Mechanism of insolubilization ...... th hereditary human cataracts.
@nl
P2860
P356
P1433
P1476
Mechanism of insolubilization ...... ith hereditary human cataracts
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P2093
Nathan Ravi
Paul D Hamilton
P2860
P304
P356
10.1021/BI800594T
P407
P577
2008-08-14T00:00:00Z