Akt-dependent and -independent mechanisms of mTOR regulation in cancer
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Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTORMetabolic Imaging to Assess Treatment Response to Cytotoxic and Cytostatic AgentsPI3K/Akt/mTOR, a pathway less recognized for staphylococcal superantigen-induced toxicityObesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issueDeconvoluting the obesity and breast cancer link: secretome, soil and seed interactionsTurning off AKT: PHLPP as a drug targetTargeting translation initiation in breast cancerAn Automated High-throughput Array Microscope for Cancer Cell Mechanics.Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersSuppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cellsBrain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptorsA phase I study of ridaforolimus in adult Chinese patients with advanced solid tumors.Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production.Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways.A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesisCell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma.Physiological regulation of Akt activity and stability.Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage.A vicious partnership between AKT and PHLDA3 to facilitate neuroendocrine tumors.Adenosine triphosphate promotes locomotor recovery after spinal cord injury by activating mammalian target of rapamycin pathway in ratsA pan-cancer proteomic perspective on The Cancer Genome Atlas.Pregnenolone sulfate and cortisol induce secretion of acyl-CoA-binding protein and its conversion into endozepines from astrocytes.Myc proteins as therapeutic targets.The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.Rapamycin inhibits VEGF-induced microvascular hyperpermeability in vivo.Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.Phosphatidylinositol 3-kinase: the oncoprotein.Dietary energy balance modulates ovarian cancer progression and metastasis.Calorie restriction and cancer prevention: a mechanistic perspective.Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMFNovel somatic mutations to PI3K pathway genes in metastatic melanomaTRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling.Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy.Regulation of protein synthesis by amino acids in muscle of neonates.Metformin prevents tobacco carcinogen--induced lung tumorigenesisMicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis.A weighty problem: metabolic perturbations and the obesity-cancer link.
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P2860
Akt-dependent and -independent mechanisms of mTOR regulation in cancer
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 07 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Akt-dependent and -independent mechanisms of mTOR regulation in cancer
@en
Akt-dependent and -independent mechanisms of mTOR regulation in cancer.
@nl
type
label
Akt-dependent and -independent mechanisms of mTOR regulation in cancer
@en
Akt-dependent and -independent mechanisms of mTOR regulation in cancer.
@nl
prefLabel
Akt-dependent and -independent mechanisms of mTOR regulation in cancer
@en
Akt-dependent and -independent mechanisms of mTOR regulation in cancer.
@nl
P2860
P1433
P1476
Akt-dependent and -independent mechanisms of mTOR regulation in cancer
@en
P2093
Phillip A Dennis
Regan M Memmott
P2860
P304
P356
10.1016/J.CELLSIG.2009.01.004
P577
2009-01-07T00:00:00Z