Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes.
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The digestive tract as the origin of systemic inflammationGut failure in critical care: old school versus new schoolTransmural intestinal wall permeability in severe ischemia after enteral protease inhibition.Endoscopy-based early enterostomy closure for superior mesenteric arterial occlusion.Loss of the intestinal mucus layer in the normal rat causes gut injury but not toxic mesenteric lymph nor lung injuryIntestinal mucus layer preservation in female rats attenuates gut injury after trauma-hemorrhagic shock.Pancreatic trypsin increases matrix metalloproteinase-9 accumulation and activation during acute intestinal ischemia-reperfusion in the rat.Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall.Impaired small-bowel barrier integrity in the presence of lumenal pancreatic digestive enzymes leads to circulatory shockIn vivo analysis of intestinal permeability following hemorrhagic shockA journey with Tony Hugli up the inflammatory cascade towards the auto-digestion hypothesisMesenteric lymph duct ligation prevents trauma/hemorrhage shock-induced cardiac contractile dysfunction.Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury.Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury.The autodigestion hypothesis for shock and multi-organ failure.Autodigestion: Proteolytic Degradation and Multiple Organ Failure in ShockThe autodigestion hypothesis: Proteolytic receptor cleavage in rheological and cardiovascular cell dysfunction1.The mucus layer is critical in protecting against ischemia-reperfusion-mediated gut injury and in the restitution of gut barrier function.Trans-Serosal Leakage of Proinflammatory Mediators during Abdominal Aortic Aneurysm Repair: Role of Phospholipase A2 in Activating Leukocytes.Pancreatic digestive enzyme blockade in the small intestine prevents insulin resistance in hemorrhagic shock.Oxidative modification of the intestinal mucus layer is a critical but unrecognized component of trauma hemorrhagic shock-induced gut barrier failure.Volatile Decay Products in Breath During Peritonitis Shock are Attenuated by Enteral Blockade of Pancreatic Digestive Proteases.Pancreatic digestive enzyme blockade in the intestine increases survival after experimental shock.Fat and the gut: more than empty caloriesSevere intestinal ischemia can trigger cardiovascular collapse and sudden death via a parasympathetic mechanism.Intraluminal nonbacterial intestinal components control gut and lung injury after trauma hemorrhagic shock.The Autodigestion Hypothesis in Shock and Multi-Organ Failure: Degrading Protease Activity.2008 Landis Award lecture. Inflammation and the autodigestion hypothesis.Enhancement of reperfusion injury by elevation of microvascular pressures.The intestine as source of cytotoxic mediators in shock: free fatty acids and degradation of lipid-binding proteins.Pancreatic duct ligation reduces lung injury following trauma and hemorrhagic shock.Biomechanical aspects of the auto-digestion theory.
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Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2000
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes.
@en
Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes.
@nl
type
label
Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes.
@en
Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes.
@nl
prefLabel
Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes.
@en
Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes.
@nl
P2093
P2860
P356
P1476
Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes.
@en
P2093
E B Kistler
G W Schmid-Schonbein
H Mitsuoka
P2860
P304
P356
10.1073/PNAS.97.4.1772
P407
P577
2000-02-01T00:00:00Z