Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice. - Wikidata - awgldk - TriplyDB

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

http://www.wikidata.org/entity/Q37119771

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Autosomal dominant polycystic kidney disease: the last 3 years Polycystic kidney disease - where gene dosage counts Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney.A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7 Novel targets for the treatment of autosomal dominant polycystic kidney disease.Treatment strategies and clinical trial design in ADPKD Evidence that TMEM67 causes polycystic kidney disease through activation of JNK/ERK-dependent pathways.Structural interaction and functional regulation of polycystin-2 by filamin Kidney: polycystic kidney disease.Cyclic AMP-mediated cyst expansion TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells.Cilia movement regulates expression of the Raf-1 kinase inhibitor protein Inhibition of the P2X7 receptor reduces cystogenesis in PKD.Filamin-a increases the stability and plasma membrane expression of polycystin-2.Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease Vasopressin and disruption of calcium signalling in polycystic kidney disease.Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice.Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease Emerging evidence of a link between the polycystins and the mTOR pathways.Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease.Calcium-mediated mechanisms of cystic expansion.Polycystic kidney disease: pathogenesis and potential therapies.Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.Polycystins and cellular Ca2+ signaling.Validation of Effective Therapeutic Targets for ADPKD Using Animal Models.Genome-wide methylation profiling of ADPKD identified epigenetically regulated genes associated with renal cyst development.Far Upstream Element-Binding Protein 1 Binds the 3' Untranslated Region of PKD2 and Suppresses Its Translation Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.Differential Expression of PKD2-Associated Genes in Autosomal Dominant Polycystic Kidney Disease.Unraveling the Mechanistic Complexity of the Glomerulocystic Phenotype in Dicer Conditional KO Mice by 2D Gel Electrophoresis Coupled Mass Spectrometry.Acute kidney injury induces hallmarks of polycystic kidney disease.N-myc downstream-regulated gene 1 is involved in the regulation of cystogenesis in transgenic mice overexpressing human PKD2 gene.Novel long-range regulatory mechanisms controlling PKD2 gene expression.

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Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

http://www.wikidata.org/entity/Q37119771

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 20 December 2008

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

@en

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

@nl

type

label

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

@en

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

@nl

prefLabel

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

@en

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

@nl

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Journal of Biological Chemistry

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Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice

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Curie Ahn

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Eun Young Park

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Goo Taeg Oh

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Han-Woong Lee

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Ingyu Kim

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Je Kyung Seong

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Ji Yeun Noh

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Jong Hoon Park

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Kyung Hyun Yoo

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Kyung Jin Roh

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P2860

Specific association of the gene product of PKD2 with the TRPC1 channel

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

Alpha-actinin associates with polycystin-2 and regulates its channel activity

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

PKD1 interacts with PKD2 through a probable coiled-coil domain

Centrosome overduplication and mitotic instability in PKD2 transgenic lines

Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling

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7214-7222

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scholarly article

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10.1074/JBC.M805890200

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11

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284

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Young-Hwan Hwang

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2008-12-20T00:00:00Z

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23679862

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19098310

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2652279

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