Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.
about
Experimental therapies and ongoing clinical trials to slow down progression of ADPKDNovel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney diseaseThe role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologiesEx vivo modeling of chemical synergy in prenatal kidney cystogenesisGenetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.Cyst formation following disruption of intracellular calcium signalingConditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease.Cyclic AMP-mediated cyst expansionCombinatorial high-throughput experimental and bioinformatic approach identifies molecular pathways linked with the sensitivity to anticancer target drugsProstaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia.Serum uric acid, kidney volume and progression in autosomal-dominant polycystic kidney disease.Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD.microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolismDrug discovery for polycystic kidney diseaseMultidrug therapy for polycystic kidney disease: a review and perspective.New treatments for autosomal dominant polycystic kidney diseaseTissue-engineered kidney disease models.New options in the treatment of autosomal dominant polycystic kidney disease.The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease.cAMP signalling in trypanosomatids: role in pathogenesis and as a drug target.Recent Trends in ADPKD Research.Validation of Effective Therapeutic Targets for ADPKD Using Animal Models.Gα12 is required for renal cystogenesis induced by Pkd1 inactivation.Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib.The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model.Mechanism-based therapeutics for autosomal dominant polycystic kidney disease: recent progress and future prospects.Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation.
P2860
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P2860
Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Sorafenib inhibits cAMP-depend ...... n ADPKD cyst epithelial cells.
@en
Sorafenib inhibits cAMP-depend ...... n ADPKD cyst epithelial cells.
@nl
type
label
Sorafenib inhibits cAMP-depend ...... n ADPKD cyst epithelial cells.
@en
Sorafenib inhibits cAMP-depend ...... n ADPKD cyst epithelial cells.
@nl
prefLabel
Sorafenib inhibits cAMP-depend ...... n ADPKD cyst epithelial cells.
@en
Sorafenib inhibits cAMP-depend ...... n ADPKD cyst epithelial cells.
@nl
P2093
P2860
P1476
Sorafenib inhibits cAMP-depend ...... n ADPKD cyst epithelial cells.
@en
P2093
Darren P Wallace
Gail A Reif
James P Calvet
Tamio Yamaguchi
P2860
P304
P356
10.1152/AJPRENAL.00387.2010
P577
2010-09-01T00:00:00Z