In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
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Multifaceted functions and roles of HBZ in HTLV-1 pathogenesisThe Role of HBZ in HTLV-1-Induced OncogenesisModes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and PersistenceImmunopathogenesis and neurological manifestations associated to HTLV-1 infectionAntisense transcription in gammaretroviruses as a mechanism of insertional activation of host genesNovel interactions between the HTLV antisense proteins HBZ and APH-2 and the NFAR protein family: Implications for the HTLV lifecyclesHTLV-1 Tax-mediated inhibition of FOXO3a activity is critical for the persistence of terminally differentiated CD4+ T cellsHLA class I binding of HBZ determines outcome in HTLV-1 infection.NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ.Epidemiology, treatment, and prevention of human T-cell leukemia virus type 1-associated diseasesHuman T cell leukemia virus type 1 infection drives spontaneous proliferation of natural killer cellsHTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice.Human T-cell leukemia virus type 3 (HTLV-3) and HTLV-4 antisense-transcript-encoded proteins interact and transactivate Jun family-dependent transcription via their atypical bZIP motifSystems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbitsHTLV-1 proviral integration sites differ between asymptomatic carriers and patients with HAM/TSP.Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathyHTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications.In vivo expression of human T-lymphotropic virus type 1 basic leucine-zipper protein generates specific CD8+ and CD4+ T-lymphocyte responses that correlate with clinical outcome.Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression.HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression.Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesisMouse models of human T lymphotropic virus type-1-associated adult T-cell leukemia/lymphoma.Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis.Making sense out of antisense transcription in human T-cell lymphotropic viruses (HTLVs).Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease.HTLV-2 APH-2 expression is correlated with proviral load but APH-2 does not promote lymphocytosis.HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals.Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy.Human T-cell leukemia virus type 1 (HTLV-1) bZIP factor requires cellular transcription factor JunD to upregulate HTLV-1 antisense transcription from the 3' long terminal repeat.Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).Immunopathogenesis of human T-cell leukemia virus type-1-associated myelopathy/tropical spastic paraparesis: recent perspectivesComplex role of microRNAs in HTLV-1 infections.Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway.Humoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individualsAbsolute quantification of HTLV-1 basic leucine zipper factor (HBZ) protein and its plasma antibody in HTLV-1 infected individuals with different clinical status.Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesisThe HBZ gene, a key player in HTLV-1 pathogenesis.The 14th International Conference on Human Retrovirology: HTLV and related retroviruses (July 1-4, 2009; Salvador, Brazil)
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In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
In vivo expression of the HBZ ...... spastic paraparesis (HAM/TSP)
@en
In vivo expression of the HBZ ...... spastic paraparesis (HAM/TSP).
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type
label
In vivo expression of the HBZ ...... spastic paraparesis (HAM/TSP)
@en
In vivo expression of the HBZ ...... spastic paraparesis (HAM/TSP).
@nl
prefLabel
In vivo expression of the HBZ ...... spastic paraparesis (HAM/TSP)
@en
In vivo expression of the HBZ ...... spastic paraparesis (HAM/TSP).
@nl
P2093
P2860
P50
P356
P1433
P1476
In vivo expression of the HBZ ...... spastic paraparesis (HAM/TSP)
@en
P2093
Kimiyoshi Arimura
Kousuke Saito
Mineki Saito
Toshio Matsuzaki
Yoshiro Ohara
P2860
P2888
P356
10.1186/1742-4690-6-19
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2009-02-19T00:00:00Z
P5875
P6179
1017949192