Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells - Wikidata - awgldk - TriplyDB

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

http://www.wikidata.org/entity/Q37123913

about

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging Significance of oncogenes and tumor suppressor genes in AML prognosis.Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.An integrated approach of gene expression and DNA-methylation profiles of WNT signaling genes uncovers novel prognostic markers in acute myeloid leukemia.Targeting cell cycle regulators in hematologic malignancies.Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis.Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knock-in mice.HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.Intracellular Signaling Pathways Involved in Childhood Acute Lymphoblastic Leukemia; Molecular Targets Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibition RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes High expression of RUNX1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia.High expression of MAP7 predicts adverse prognosis in young patients with cytogenetically normal acute myeloid leukemia ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.Targeting binding partners of the CBFβ-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia.Posttranslational modifications of RUNX1 as potential anticancer targets.A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis The RUNX family: developmental regulators in cancer.The RUNX1-PU.1 axis in the control of hematopoiesis.A minicircuitry of microRNA-9-1 and RUNX1-RUNX1T1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.Runx1 Structure and Function in Blood Cell Development.RUNX3 facilitates growth of Ewing sarcoma cells Role of RUNX1 in hematological malignancies.Molecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid Leukemia.Covalent Modifications of RUNX Proteins: Structure Affects Function.Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia.Myeloid neoplasms with germ line RUNX1 mutation.Molecular signatures of ovarian diseases: Insights from network medicine perspective.Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells.

P2860

Q27311229-54A210BE-56F6-46FF-940B-EB0D74612F18 Q30250315-4313B4B1-8786-4EDB-9455-0B5E87BE966B Q30252938-117EEF49-52C9-471C-8C31-261CAFD042F0 Q30276341-E040B57B-175F-46A0-BE7A-3A8D4E605925 Q33419236-14E9F68C-76EC-4584-A6DB-9A7D5D2EDFD5 Q33794291-5DBFDCA2-A844-4255-9FE4-16A99B8F8877 Q34318485-EC8A3BC2-A434-4ED0-99D6-4C65767993FA Q34718209-F7037631-6BB7-4A74-A8B5-6B8994AA08F1 Q35018755-7547DA03-7D4F-407A-A279-0F53DB528326 Q35141163-9815426E-3DE7-4225-B34A-71DB746BD5F8 Q35334436-3551E459-4F04-4525-9FC7-126A5668EDB8 Q35806108-6A2EA654-26D0-47EA-82D6-76E76900A0F5 Q35903884-EA1FDA8E-1BDC-462C-9331-61927B37EAA9 Q35920680-4CE1E8E8-09F6-4BFB-8510-8B9CA45A131E Q36259601-2B286398-ED39-4B40-A0AC-1C2314F631A1 Q36442414-97B17429-A4B8-4841-811D-CB10FBDE4238 Q36463590-7E568E86-3065-476C-9D57-33D542617DBE Q36642902-17D72DA3-5406-4D3D-97C2-67EF4C261B55 Q36679531-10DD9B2D-CF5C-4CAB-BE7C-385AA7CFB6EF Q36827373-33629E23-3B2A-4FF2-974E-608189172857 Q36916273-9832A759-4734-4D47-B026-D63CC7AEB903 Q37085891-7D594BE2-65B8-49A4-9EA7-EFEA6682DA3F Q37298691-64A64149-C959-4354-BC83-8A66FB88AE0C Q37437486-D0799A60-13BA-4EDC-924D-0DF15C5572E2 Q37662400-2E57A7B2-BEAD-48F0-A115-C40CADD089F8 Q38255068-C60B052A-A164-4EA3-9FED-307A772B6F91 Q38260410-A482ACAD-0FF3-4C6C-8407-371F8F7C85BC Q38319972-1ED290D0-E768-4823-A46B-6CA9488D1FC6 Q38370113-D3C0252E-80E7-44CF-8437-8D86062FD1A2 Q38738895-7187357B-4934-440D-BF3B-D22DA9EF30AF Q38768286-E5E05866-E3A4-4D2B-BE2F-34C116F9BEC8 Q38904253-0BED0E4D-0B12-4A38-88B2-4CE861A1A99D Q38996845-8C3FD1C5-9542-4B58-BB89-B4C137C355E1 Q39127024-CCE27596-621A-4290-BB03-BD0C42AAC799 Q39135620-7B3D9E0B-1B9E-4E70-AC14-DCDF657E1ED1 Q39181397-DA69034E-C412-4A36-8FA0-0085ACBE5E39 Q39209792-2B8CE038-5A80-4D94-8F42-2A34E1388BF9 Q39324039-6B2AE54F-4B49-48FA-A521-5B6DDDB34620 Q39657304-71C80695-A4A9-43C0-ADD3-09DD06E01DAA Q40293334-E208701C-8446-4056-9D61-061CDF40C276

P2860

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

http://www.wikidata.org/entity/Q37123913

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 27 August 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

@en

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells.

@nl

type

label

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

@en

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells.

@nl

prefLabel

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

@en

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells.

@nl

P1433

Q37123913-47101031-0A55-4B5B-85A3-F5D2B24520B2

P1476

Q37123913-33DEDB4E-8764-4713-BB28-CDC5EB443228

P2093

Q37123913-1C3496F7-EE06-4E13-BBE9-26789B731AF5

Q37123913-22F3F010-65DC-444A-B180-FEC85511DED3

Q37123913-3B654C0D-5A26-48E4-BB0C-B375B5451B26

Q37123913-3CFE8DAD-3771-471B-8CAC-B18DEF45A01C

Q37123913-49E17826-D2EF-48C7-92D3-8FE19137AED7

Q37123913-544B4327-3855-482D-A50F-0A7E2F227B1A

Q37123913-64A41951-A959-47E4-84F2-BA874AAC52BC

Q37123913-9217EDD5-212E-4564-8F8E-1624F0BA7A2E

Q37123913-AAAD1891-0B15-468D-8F99-CBC86D505E45

Q37123913-AB3ECC27-0778-4BAB-B487-D0D9DC4379D1

P2860

Q37123913-01532118-BBF1-4A76-988D-76E331D0329B

Q37123913-07556231-BB90-4BAD-BFE7-5C3E1E6E85B7

Q37123913-07B98260-67CC-413E-A1DD-F9E3D068833A

Q37123913-08CAD461-849D-4DC2-8FA0-92ACF03C28A0

Q37123913-10EB70C1-E58B-4E88-A4B0-2E773D5B945C

Q37123913-12BA3745-809C-4B6A-B39B-8C855DA48C3E

Q37123913-185C2DD6-5F2F-45DA-BFB0-72F1E34EC5A4

Q37123913-1BB8EB38-F940-4622-9DA3-4D815E141071

Q37123913-1EEB9BC4-F03A-4E85-BADD-B61B39653B4F

Q37123913-20A99C2E-6C66-4203-8E63-AAC9AE6B479C

P304

Q37123913-63F59398-6E9B-402E-90D8-4E059CD8A601

P31

Q37123913-7B600DD5-D342-4FD2-B8D8-D2913E7F8296

P356

Q37123913-02C4727D-B226-4995-8CCA-C6CB6FDD6D37

P407

Q37123913-1554D5A8-D193-48CB-A93D-A1ABFC4E0E7C

P433

Q37123913-C0A6CDB7-8AAA-4932-8466-B333763D424A

P478

Q37123913-41222A6D-4474-4E16-9BBB-32C70E2353CB

P50

Q37123913-39A58A36-3C0F-47E2-BB42-09AA2BF4A70E

Q37123913-BCF259F7-B0FD-456C-9733-F742748ED29F

P577

Q37123913-17A73E4E-4393-48E7-BBB9-8403734B45D7

P5875

Q37123913-B2AB88CD-A182-4ABB-8F12-18E2C457E96D

P698

Q37123913-5A87D101-3184-4F97-B717-37F6B362AE99

P921

Q37123913-CBB428F8-571C-4275-834A-6697B3F95472

P932

Q37123913-21FDC8EC-374E-4A8D-B3EE-B8BA1513B576

P356

P1433

Journal of Clinical Investigation

P1476

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

@en

P2093

Andre Olsson

http://www.w3.org/2001/XMLSchema#string

Benjamin Mizukawa

http://www.w3.org/2001/XMLSchema#string

Gang Huang

http://www.w3.org/2001/XMLSchema#string

James C Mulloy

http://www.w3.org/2001/XMLSchema#string

Janet Schibler

http://www.w3.org/2001/XMLSchema#string

Kevin A Link

http://www.w3.org/2001/XMLSchema#string

Lea Cunningham

http://www.w3.org/2001/XMLSchema#string

Mark Wunderlich

http://www.w3.org/2001/XMLSchema#string

Mineo Kurokawa

http://www.w3.org/2001/XMLSchema#string

Nahoko Nishimoto

http://www.w3.org/2001/XMLSchema#string

P2860

Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling.

P304

3876-3888

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI68557

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

123

http://www.w3.org/2001/XMLSchema#string

P50

H. Leighton Grimes

Masahiro Nakagawa

P577

2013-08-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

256119211

http://www.w3.org/2001/XMLSchema#string

P698

23979164

http://www.w3.org/2001/XMLSchema#string

P921

P932

3754260

http://www.w3.org/2001/XMLSchema#string