Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum
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Exploiting Structural Analysis, in Silico Screening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum MalariaFirst Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate ChannelingExploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein–protein interaction in C. hominis thymidylate synthase-dihydrofolate reductase (TS-DHFR)Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malariaPurine and pyrimidine pathways as targets in Plasmodium falciparum.Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis.Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR.Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation.Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax.
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Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 January 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Probing the role of parasite-s ...... ase from Plasmodium falciparum
@en
Probing the role of parasite-s ...... se from Plasmodium falciparum.
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type
label
Probing the role of parasite-s ...... ase from Plasmodium falciparum
@en
Probing the role of parasite-s ...... se from Plasmodium falciparum.
@nl
prefLabel
Probing the role of parasite-s ...... ase from Plasmodium falciparum
@en
Probing the role of parasite-s ...... se from Plasmodium falciparum.
@nl
P2860
P356
P1433
P1476
Probing the role of parasite-s ...... ase from Plasmodium falciparum
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P2093
Karen S Anderson
Tina Dasgupta
P2860
P304
P356
10.1021/BI701624U
P407
P577
2008-01-12T00:00:00Z