Natural product inhibitors of Hsp90: potential leads for drug discovery
about
Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative diseasePhysiological regulation of Akt activity and stability.HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible wayLoss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulationProbing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.Modulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes.Heat shock response and insulin-associated neurodegeneration.A systematic protocol for the characterization of Hsp90 modulators.Potent antitrypanosomal activities of heat shock protein 90 inhibitors in vitro and in vivo.Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases.Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics.HSP90: chaperone-me-not.Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?Transcriptional and posttranscriptional regulation and endocytosis were involved in zinc oxide nanoparticle-induced interleukin-8 overexpression in human bronchial epithelial cells.Discovery and biological activity of 6BrCaQ as an inhibitor of the Hsp90 protein folding machinery.Screening of Neem extracts for microbial anti-chaperone activity by employing in vitro enzyme refolding assay.Hsp90 inhibitor celastrol reinstates growth plate angiogenesis in thiram-induced tibial dyschondroplasia.
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Natural product inhibitors of Hsp90: potential leads for drug discovery
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on February 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Natural product inhibitors of Hsp90: potential leads for drug discovery
@en
Natural product inhibitors of Hsp90: potential leads for drug discovery.
@nl
type
label
Natural product inhibitors of Hsp90: potential leads for drug discovery
@en
Natural product inhibitors of Hsp90: potential leads for drug discovery.
@nl
prefLabel
Natural product inhibitors of Hsp90: potential leads for drug discovery
@en
Natural product inhibitors of Hsp90: potential leads for drug discovery.
@nl
P2860
P1476
Natural product inhibitors of Hsp90: potential leads for drug discovery
@en
P2093
B S J Blagg
M W Amolins
P2860
P304
P356
10.2174/138955709787316056
P577
2009-02-01T00:00:00Z