Pharmaceutical and pharmacological importance of peptide transporters.
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Mouse endogenous retroviruses can trigger premature transcriptional termination at a distanceStructural basis for polyspecificity in the POT family of proton-coupled oligopeptide transportersData Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson SyndromeBioavailability through PepT1: the role of computer modelling in intelligent drug design.Expression and regulation of the proton-coupled oligopeptide transporter PhT2 by LPS in macrophages and mouse spleen.GLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic β-cells from glucolipotoxicityRandom mutagenesis of the prokaryotic peptide transporter YdgR identifies potential periplasmic gating residuesEnhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null miceSignificance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout miceBrainpeps: the blood-brain barrier peptide database.Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null miceExpression profile and functional activity of peptide transporters in prostate cancer cells.Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and ratPeptide transporter 1 is responsible for intestinal uptake of the dipeptide glycylsarcosine: studies in everted jejunal rings from wild-type and Pept1 null miceEffect of transporter inhibition on the distribution of cefadroxil in rat brainAnalysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library.Peptide transporter DtpA has two alternate conformations, one of which is promoted by inhibitor binding.Effect of dose escalation on the in vivo oral absorption and disposition of glycylsarcosine in wild-type and Pept1 knockout mice.Influence of fed-fasted state on intestinal PEPT1 expression and in vivo pharmacokinetics of glycylsarcosine in wild-type and Pept1 knockout mice.The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease.The effects of intralaboratory modifications to media composition and cell source on the expression of pharmaceutically relevant transporters and metabolizing genes in the Caco-2 cell lineSpecies-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1.Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice.Relevance of PepT1 in the intestinal permeability and oral absorption of cefadroxilProton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications.The proton-coupled oligopeptide transporter 1 plays a major role in the intestinal permeability and absorption of 5-aminolevulinic acidSpecies differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 miceFunctional and molecular expression of the proton-coupled oligopeptide transporters in spleen and macrophages from mouse and humanEffective Delivery of Male Contraceptives Behind the Blood-Testis Barrier (BTB) - Lesson from Adjudin.Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir Following Intravenous and Oral Administrations in Rats: A Study Involving In vivo Corneal Uptake of Acyclovir Following Oral Dosing.THE EVALUATION OF PEPTIDE/HISTIDINE TRANSPORTER 1 (PHT1) FUNCTION: UPTAKE KINETICS UTILIZING A COS-7 STABLY TRANSFECTED CELL LINEFunctional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE.Impact of peptide transporter 1 on the intestinal absorption and pharmacokinetics of valacyclovir after oral dose escalation in wild-type and PepT1 knockout mice.Impact of intestinal PepT1 on the kinetics and dynamics of N-formyl-methionyl-leucyl-phenylalanine, a bacterially-produced chemotactic peptide.In vivo absorption and disposition of cefadroxil after escalating oral doses in wild-type and PepT1 knockout mice.Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestineTransport of drugs by proton-coupled peptide transporters: pearls and pitfalls.In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1.Transporters, Trojan horses and therapeutics: suitability of bile acid and peptide transporters for drug delivery.Mechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality.
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Pharmaceutical and pharmacological importance of peptide transporters.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Pharmaceutical and pharmacological importance of peptide transporters.
@en
Pharmaceutical and pharmacological importance of peptide transporters.
@nl
type
label
Pharmaceutical and pharmacological importance of peptide transporters.
@en
Pharmaceutical and pharmacological importance of peptide transporters.
@nl
prefLabel
Pharmaceutical and pharmacological importance of peptide transporters.
@en
Pharmaceutical and pharmacological importance of peptide transporters.
@nl
P2860
P356
P1476
Pharmaceutical and pharmacological importance of peptide transporters.
@en
P2093
Eva Bosse-Doenecke
Matthias Brandsch
P2860
P304
P356
10.1211/JPP.60.5.0002
P50
P577
2008-05-01T00:00:00Z