Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector
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Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNAAdeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success--a personal perspectiveRoles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombinationGenetic fate of recombinant adeno-associated virus vector genomes in muscleDirected evolution of adeno-associated virus for glioma cell transductionAdeno-associated virus vectors and hematologyAdeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat.A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector.DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectorsHigh-efficiency transduction of primary human hematopoietic stem cells and erythroid lineage-restricted expression by optimized AAV6 serotype vectors in vitro and in a murine xenograft model in vivop53 inhibits adeno-associated viral vector integrationParvovirus particles as platforms for protein presentationAdeno-associated virus vectors preferentially transduce cells in S phase.Transduction of folate receptor cDNA into cervical carcinoma cells using recombinant adeno-associated virions delays cell proliferation in vitro and in vivo.Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells.Recombinant adeno-associated virus-mediated high-efficiency, transient expression of the murine cationic amino acid transporter (ecotropic retroviral receptor) permits stable transduction of human HeLa cells by ecotropic retroviral vectors.Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector.Adeno-associated virus type 2-mediated transduction of murine hematopoietic cells with long-term repopulating ability and sustained expression of a human globin gene in vivo.Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles.Adeno-associated virus vector integration junctions.Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase.Suppression of human alpha-globin gene expression mediated by the recombinant adeno-associated virus 2-based antisense vectorsAdeno-associated virus 2-mediated high efficiency gene transfer into immature and mature subsets of hematopoietic progenitor cells in human umbilical cord blood.Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectorsEfficient gene transfer into nondividing cells by adeno-associated virus-based vectors.Novel adeno-associated virus vector vaccine restricts replication of simian immunodeficiency virus in macaques.Development of gene therapy for thalassemia.Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience.Slow and Steady Wins The Race? Progress in the Development of Vectors for Gene Therapy of β-Thalassemia and Sickle Cell Disease.Practical utilization of recombinant AAV vector reference standards: focus on vector genomes titration by free ITR qPCR.A novel 165-base-pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle.Recombinant adeno-associated virus mediates a high level of gene transfer but less efficient integration in the K562 human hematopoietic cell lineAdeno-associated virus Rep78 protein and terminal repeats enhance integration of DNA sequences into the cellular genome.Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'gamma)2 antibody.Human gene targeting by viral vectors.High volume naked DNA tail-vein injection restores liver function in Fah-knock out mice.Efficient gene transfer into human cord blood CD34+ cells and the CD34+CD38- subset using highly purified recombinant adeno-associated viral vector preparations that are free of helper virus and wild-type AAV.
P2860
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P2860
Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Regulated high level expressio ...... adeno-associated virus vector
@en
Regulated high level expressio ...... adeno-associated virus vector.
@nl
type
label
Regulated high level expressio ...... adeno-associated virus vector
@en
Regulated high level expressio ...... adeno-associated virus vector.
@nl
prefLabel
Regulated high level expressio ...... adeno-associated virus vector
@en
Regulated high level expressio ...... adeno-associated virus vector.
@nl
P2093
P2860
P356
P1476
Regulated high level expressio ...... adeno-associated virus vector
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.15.7257
P407
P577
1992-08-01T00:00:00Z