Adeno-associated virus Rep78 protein and terminal repeats enhance integration of DNA sequences into the cellular genome.
about
The adeno-associated virus type 2 regulatory proteins rep78 and rep68 interact with the transcriptional coactivator PC4.Efficient replication of adeno-associated virus type 2 vectors: a cis-acting element outside of the terminal repeats and a minimal sizeEfficient integration of recombinant adeno-associated virus DNA vectors requires a p5-rep sequence in cis.The effect of DNA-dependent protein kinase on adeno-associated virus replicationRoles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombinationAdeno-associated virus site-specifically integrates into a muscle-specific DNA regionDesigner gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transferDevelopment of animal models for adeno-associated virus site-specific integration.Adeno-associated virus vectors and hematologyStable secondary structure near the nicking site for adeno-associated virus type 2 Rep proteins on human chromosome 19Adeno-associated virus vector-mediated transgene integration into neurons and other nondividing cell targets.Conditional site-specific integration into human chromosome 19 by using a ligand-dependent chimeric adeno-associated virus/Rep protein.A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay.Mutational analysis of adeno-associated virus type 2 Rep68 protein endonuclease activity on partially single-stranded substrates.Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver.Factors affecting the terminal resolution site endonuclease, helicase, and ATPase activities of adeno-associated virus type 2 Rep proteinsAmino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro.Four-dimensional visualization of the simultaneous activity of alternative adeno-associated virus replication origins.HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part II. Vector systems and applicationsSubstitution of adeno-associated virus Rep protein binding and nicking sites with human chromosome 19 sequences.Rapid establishment of a HEK 293 cell line expressing FVIII-BDD using AAV site-specific integration plasmids.Herpes simplex virus type 1/adeno-associated virus rep(+) hybrid amplicon vector improves the stability of transgene expression in human cells by site-specific integration.Herpes simplex virus type 1/adeno-associated virus hybrid vectors mediate site-specific integration at the adeno-associated virus preintegration site, AAVS1, on human chromosome 19.Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector.Efficient recombinase-mediated cassette exchange at the AAVS1 locus in human embryonic stem cells using baculoviral vectors.Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectorsAdeno-associated virus (AAV) site-specific integration: formation of AAV-AAVS1 junctions in an in vitro system.Characterization of the mouse adeno-associated virus AAVS1 ortholog.Identification of cellular proteins that interact with the adeno-associated virus rep proteinNon-viral adeno-associated virus-based platform for stable expression of antibody combination therapeutics.A helper-dependent capsid-modified adenovirus vector expressing adeno-associated virus rep78 mediates site-specific integration of a 27-kilobase transgene cassette.Selective cleavage of AAVS1 substrates by the adeno-associated virus type 2 rep68 protein is dependent on topological and sequence constraints.Comparative characterization of rep proteins from the helper-dependent adeno-associated virus type 2 and the autonomous goose parvovirus.Gene therapy vectors based on adeno-associated virus type 1.Lipofection of purified adeno-associated virus Rep68 protein: toward a chromosome-targeting nonviral particle.Site-specific integration in mammalian cells mediated by a new hybrid baculovirus-adeno-associated virus vector.Site-specific integration of an adeno-associated virus vector plasmid mediated by regulated expression of rep based on Cre-loxP recombination.DNA sequence motifs which direct adeno-associated virus site-specific integration in a model system.Characteristics of the adeno-associated virus preintegration site in human chromosome 19: open chromatin conformation and transcription-competent environment.Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes.
P2860
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P2860
Adeno-associated virus Rep78 protein and terminal repeats enhance integration of DNA sequences into the cellular genome.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Adeno-associated virus Rep78 p ...... nces into the cellular genome.
@en
Adeno-associated virus Rep78 p ...... nces into the cellular genome.
@nl
type
label
Adeno-associated virus Rep78 p ...... nces into the cellular genome.
@en
Adeno-associated virus Rep78 p ...... nces into the cellular genome.
@nl
prefLabel
Adeno-associated virus Rep78 p ...... nces into the cellular genome.
@en
Adeno-associated virus Rep78 p ...... nces into the cellular genome.
@nl
P2093
P2860
P1433
P1476
Adeno-associated virus Rep78 p ...... nces into the cellular genome.
@en
P2093
P2860
P304
P407
P577
1997-04-01T00:00:00Z