The role of ligands on the equilibria between functional states of a G protein-coupled receptor. - Wikidata - awgldk - TriplyDB

The role of ligands on the equilibria between functional states of a G protein-coupled receptor.

The role of ligands on the equilibria between functional states of a G protein-coupled receptor.

http://www.wikidata.org/entity/Q37149545

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Constitutively active rhodopsin and retinal disease G-Protein/β-Arrestin-Linked Fluctuating Network of G-Protein-Coupled Receptors for Predicting Drug Efficacy and Bias Using Short-Term Molecular Dynamics Simulation A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹⁹F NMR studies of proteins.Solvent-accessibility of discrete residue positions in the polypeptide hormone glucagon by 19F-NMR observation of 4-fluorophenylalanine.Nanobodies to Study G Protein-Coupled Receptor Structure and Function.Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor.Differences in allosteric communication pipelines in the inactive and active states of a GPCR.Fluorinated aromatic amino acids are sensitive 19F NMR probes for bromodomain-ligand interactions.Small expression tags enhance bacterial expression of the first three transmembrane segments of the apelin receptor.Agonist binding by the β2-adrenergic receptor: an effect of receptor conformation on ligand association-dissociation characteristics Deconvolution of Complex 1D NMR Spectra Using Objective Model Selection Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction Investigation of allosteric coupling in human β2-adrenergic receptor in the presence of intracellular loop 3.Can Specific Protein-Lipid Interactions Stabilize an Active State of the Beta 2 Adrenergic Receptor?Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR.Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptor Correlation of chemical shifts predicted by molecular dynamics simulations for partially disordered proteins Propagation of conformational changes during μ-opioid receptor activation.Conserved Mechanism of Conformational Stability and Dynamics in G-Protein-Coupled Receptors.Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the β₂-adrenergic receptor Functional assay for T4 lysozyme-engineered G protein-coupled receptors with an ion channel reporter.Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs.The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin.In-Membrane Chemical Modification (IMCM) for Site-Specific Chromophore Labeling of GPCRs Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes.Ring current shifts in (19)F-NMR of membrane proteins.Functional dynamics of deuterated β2 -adrenergic receptor in lipid bilayers revealed by NMR spectroscopy.Mechanistic insights into GPCR-G protein interactions.β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop.Applications of NMR to membrane proteins.Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.Graph analysis of β2 adrenergic receptor structures: a "social network" of GPCR residues.Toward an understanding of agonist binding to human Orexin-1 and Orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis.Expression, Functional Characterization, and Solid-State NMR Investigation of the G Protein-Coupled GHS Receptor in Bilayer Membranes β₂-adrenergic receptor activation by agonists studied with ¹⁹F NMR spectroscopy.Computational design of ligand-binding membrane receptors with high selectivity.Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor.Dynamical Binding Modes Determine Agonistic and Antagonistic Ligand Effects in the Prostate-Specific G-Protein Coupled Receptor (PSGR).Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor.

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The role of ligands on the equilibria between functional states of a G protein-coupled receptor.

http://www.wikidata.org/entity/Q37149545

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 14 June 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

The role of ligands on the equ ...... a G protein-coupled receptor.

@en

The role of ligands on the equ ...... a G protein-coupled receptor.

@nl

type

label

The role of ligands on the equ ...... a G protein-coupled receptor.

@en

The role of ligands on the equ ...... a G protein-coupled receptor.

@nl

prefLabel

The role of ligands on the equ ...... a G protein-coupled receptor.

@en

The role of ligands on the equ ...... a G protein-coupled receptor.

@nl

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Journal of the American Chemical Society

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The role of ligands on the equ ...... a G protein-coupled receptor.

@en

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David E Shaw

http://www.w3.org/2001/XMLSchema#string

Ka Young Chung

http://www.w3.org/2001/XMLSchema#string

R Scott Prosser

http://www.w3.org/2001/XMLSchema#string

Ron O Dror

http://www.w3.org/2001/XMLSchema#string

Tae Hun Kim

http://www.w3.org/2001/XMLSchema#string

Thomas J Mildorf

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

Diversity and modularity of G protein-coupled receptor structures

Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

Nanobody stabilization of G protein-coupled receptor conformational states.

Intrinsic dynamics of an enzyme underlies catalysis

The role of dynamic conformational ensembles in biomolecular recognition

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9465-9474

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scholarly article

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10.1021/JA404305K

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25

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135

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Alexandar L Hansen

Aashish Manglik

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2013-06-14T00:00:00Z

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23721409

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G protein-coupled receptor

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3763947

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