BRCA1 and BRCA2: different roles in a common pathway of genome protection. - Wikidata - awgldk - TriplyDB

BRCA1 and BRCA2: different roles in a common pathway of genome protection.

BRCA1 and BRCA2: different roles in a common pathway of genome protection.

http://www.wikidata.org/entity/Q37149848

about

Human single-stranded DNA binding proteins are essential for maintaining genomic stability Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1 Unbalanced replication as a major source of genetic instability in cancer cells Targeting DNA Replication Stress for Cancer Therapy Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders Interplay between Fanconi anemia and homologous recombination pathways in genome integrity Pancreatic Cancer Genetics Genetics and biology of pancreatic ductal adenocarcinoma When ubiquitin meets NF-κB: a trove for anti-cancer drug development The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2 Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising OLA1 in centrosome biology alongside the BRCA1/BARD1 complex: looking beyond centrosomes The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2 Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3 RANKL/RANK: from bone loss to the prevention of breast cancer Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination The microRNA-183 cluster: the family that plays together stays together Prediction of Genetic Interactions Using Machine Learning and Network Properties miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research BRCA1 and Oxidative Stress The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer Evolution of pre-existing versus acquired resistance to platinum drugs and PARP inhibitors in BRCA-associated cancers IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells Exome-wide somatic microsatellite variation is altered in cells with DNA repair deficiencies Clinical and molecular characterization of the BRCA2 p.Asn3124Ile variant reveals substantial evidence for pathogenic significance.Identifying mutation specific cancer pathways using a structurally resolved protein interaction network.Assessment of the Prognostic Value of Two Common Variants of BRCA1 and BRCA2 Genes in Ovarian Cancer Patients Treated with Cisplatin and Paclitaxel: A Gynecologic Oncology Group Study Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure Hereditary breast cancer: ever more pieces to the polygenic puzzle.

P2860

Q21263027-CA21F11E-33FC-4961-B37C-712DA1FD0469 Q24293084-4AA29FFD-F45D-4CA6-B2EF-18E03BE5F5E2 Q24303791-798F57C5-A3F1-42D1-B007-C4906975C8BE Q24328790-4BF772D5-D3B7-4336-B143-9EAD8AA77BE0 Q24338777-CDF133D0-3E46-47A7-824F-1EEC6B301892 Q24600363-1B42D4D4-D4F6-45AE-BF75-21F158F0153E Q24621737-43DF86FF-DD06-4263-ABF3-5F5C497E716F Q26739923-7879A95F-63EE-43C0-84DB-456B951631AE Q26744443-2A871BD5-2ADD-40C1-A54E-4F0A7DB6BCB9 Q26753126-25A7CDE5-F9F5-4A90-9BF6-8481696857C5 Q26765235-2ED85C9F-9241-4378-864C-93133BE1117E Q26765438-CCE348EF-9FCB-41C1-99DD-1CFD15B28489 Q26827754-334A9A98-C301-4AFC-909B-B4D7A2FD742E Q26851138-0E8639F8-FD79-4E04-8472-F2DFF2D7CCCA Q26851813-97668D59-E8F1-4427-AC96-995391C42CCE Q26863501-8F112301-60AF-4C8A-8D3A-87D095064A9F Q27009517-BD2FA250-F40C-48D5-BD83-390930701187 Q27026264-CD159844-6B08-4188-9F82-551F9CB10064 Q27027503-7326B866-1DF2-4A80-B256-7F8180956548 Q27308072-A4566584-AA91-4C66-B6BC-EF9A689EACEC Q28066320-23170ADE-E08E-4648-8FC1-DD40C8CDEEB7 Q28067393-548E2A10-BFB6-4FFA-A38F-FE56E6A06305 Q28075004-AA0DF73F-E1AB-47F4-9AE8-6D94EBE35CCF Q28077896-3C3B2F9D-1DFF-4C10-9E11-93A12B94228D Q28080473-528065CF-15A8-4220-9107-B6B81C6658C5 Q28084302-2F2C0DF2-81AA-476B-95CC-0B95418F6205 Q28267333-8C78C1FB-532A-4208-BA88-DF67D42EBA79 Q28388726-BD4AA1B7-2093-420E-A246-6E86E65D06FA Q28388921-DCB2EA7D-CC8A-47A5-AE2D-62CB24877EAB Q28485982-9B9FAB0A-5B04-4267-B010-60A5BBD294E0 Q28505250-8B5F0BC7-9AD5-4328-A754-1F66F01A6AC4 Q28538059-BE910F92-1F8B-4DB0-80D6-B1DDF658FBCD Q28542563-D3AC6D96-1395-4F64-BA6F-18D73F5F1983 Q28551043-91FD1217-31BC-4921-8056-8BF36FDD3A17 Q28652092-0F581A04-04C2-4ACD-8C85-54693D93FB89 Q30361333-BC6EAC1A-7C62-4E7A-AF1D-D91E94F4585A Q30370822-375B97A9-E1C3-45F1-9251-88EB4B985ACB Q30417640-B3A3D8E8-CCF5-44FE-8555-03F92002051C Q30578079-C638FD7E-D050-49BF-B095-C4A8D970541F Q33356511-05028236-70D2-49B6-B35F-25150EA100AE

P2860

BRCA1 and BRCA2: different roles in a common pathway of genome protection.

http://www.wikidata.org/entity/Q37149848

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 23 December 2011

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

BRCA1 and BRCA2: different roles in a common pathway of genome protection.

@en

BRCA1 and BRCA2: different roles in a common pathway of genome protection.

@nl

type

label

BRCA1 and BRCA2: different roles in a common pathway of genome protection.

@en

BRCA1 and BRCA2: different roles in a common pathway of genome protection.

@nl

prefLabel

BRCA1 and BRCA2: different roles in a common pathway of genome protection.

@en

BRCA1 and BRCA2: different roles in a common pathway of genome protection.

@nl

P1433

Q37149848-53A580CF-B6DE-4549-A993-694A6F93E17D

P1476

Q37149848-D0A55C22-2659-4BA0-926C-8950D42C753C

P2093

Q37149848-232CD067-EA85-49AD-A03F-DE3DDC934790

Q37149848-AE166A87-85CB-4572-B7D7-E9A3DCB784AD

Q37149848-F3925BF6-28A3-4479-8AFA-5E55911618AD

P2860

Q37149848-06105506-43B4-4B9C-8730-2F42FC8B5E17

Q37149848-071AA16A-94FF-421B-9A1E-3AB5C5F36EEE

Q37149848-08D4DBC8-1AA9-4F83-9304-771504C49659

Q37149848-0A7BE113-CE11-4729-8F1A-D683D358DE58

Q37149848-10AE2766-6F44-4C7A-90CB-68FA338AEF2D

Q37149848-12791DC4-6BD7-434D-8AB5-CA33BDB6F18F

Q37149848-131E5A41-725D-44FD-B250-2F0D285F9F3A

Q37149848-1592444D-FA35-4CB2-91C9-49A141243137

Q37149848-15B12F19-1450-4E05-AD20-A126CCD7411A

Q37149848-18563C02-FECD-47ED-871D-7B6FAE4DC20B

P2888

Q37149848-B7C5967D-591F-48F9-B161-DE9AA144D2BD

P304

Q37149848-3A4D6C97-4195-4CEE-9B23-FAC25BAFF92E

P31

Q37149848-2416F42E-F147-4148-B437-95651A604B3A

P356

Q37149848-60B92891-C495-4733-AFFE-BBFAF262281C

P407

Q37149848-FF6F429F-B90B-4330-A8CA-E1C0581647E6

P433

Q37149848-9F8E8DF2-3230-4DB2-8953-A5C2B01F8142

P478

Q37149848-21E870C6-0DC1-46C6-A25C-6457F6051FA0

P577

Q37149848-D56F3B46-6910-4AB4-8DA0-6F66EB162281

P5875

Q37149848-2836A6EE-07BD-4A89-A0F1-0CD8187F9062

P6179

Q37149848-55D8FDDC-E182-47A6-B256-27E253382AC2

P698

Q37149848-0775CC24-82E8-4F1C-8882-E34583FE1CFE

P932

Q37149848-29167ED7-AC31-484C-A769-5F7D8F5552AE

P356

P1433

Nature Reviews Cancer

P1476

BRCA1 and BRCA2: different roles in a common pathway of genome protection.

@en

P2093

Jarin Chun

http://www.w3.org/2001/XMLSchema#string

Rohini Roy

http://www.w3.org/2001/XMLSchema#string

Simon N Powell

http://www.w3.org/2001/XMLSchema#string

P2860

Roles of BRCA1 and its interacting proteins

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase

Purified human BRCA2 stimulates RAD51-mediated recombination

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

Structural basis for recruitment of BRCA2 by PALB2

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

P2888

P304

68-78

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NRC3181

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

12

http://www.w3.org/2001/XMLSchema#string

P577

2011-12-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51919619

http://www.w3.org/2001/XMLSchema#string

P6179

1016615579

http://www.w3.org/2001/XMLSchema#string

P698

22193408

http://www.w3.org/2001/XMLSchema#string

P932

4972490

http://www.w3.org/2001/XMLSchema#string