The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells
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Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell deathPhenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cellsThe Japanese Mutant Aβ (ΔE22-Aβ1−39) Forms Fibrils Instantaneously, with Low-Thioflavin T Fluorescence: Seeding of Wild-Type Aβ1−40into Atypical Fibrils by ΔE22-Aβ1−39Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation.Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport.Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid depositsProtein C mutation (A267T) results in ER retention and unfolded protein response activation.Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease.The Interface between Cytoskeletal Aberrations and Mitochondrial Dysfunction in Alzheimer's Disease and Related DisordersIn vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway.Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers.Cerebral amyloidosis: amyloid subunits, mutants and phenotypes.Development of new fusion proteins for visualizing amyloid-β oligomers in vivoSyntaxin 5 Overexpression and β-Amyloid 1-42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone ExposureDirect binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station.The unfolded protein response in Alzheimer's disease.Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease.Induced pluripotent stem cells and their use in cardiac and neural regenerative medicineEnhanced amyloidogenic processing of amyloid precursor protein and cell death under prolonged endoplasmic reticulum stress in brain endothelial cells.Phospholipid transfer protein (PLTP) deficiency accelerates memory dysfunction through altering amyloid precursor protein (APP) processing in a mouse model of Alzheimer's disease.Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A2 in a spatial-specific manner.Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin miceScutellaria baicalensis stem-leaf total flavonoid reduces neuronal apoptosis induced by amyloid beta-peptide (25-35).E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity.Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons.Structural dynamics of the ΔE22 (Osaka) familial Alzheimer's disease-linked amyloid β-protein.Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons.Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers.Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide.The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol-mediated intracellular amyloid β toxicity via its impaired cholesterol efflux.Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers.Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane.Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease.The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.
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The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The E693Delta mutation in amyl ...... ed apoptosis in cultured cells
@en
The E693Delta mutation in amyl ...... d apoptosis in cultured cells.
@nl
type
label
The E693Delta mutation in amyl ...... ed apoptosis in cultured cells
@en
The E693Delta mutation in amyl ...... d apoptosis in cultured cells.
@nl
prefLabel
The E693Delta mutation in amyl ...... ed apoptosis in cultured cells
@en
The E693Delta mutation in amyl ...... d apoptosis in cultured cells.
@nl
P2093
P2860
P1476
The E693Delta mutation in amyl ...... ed apoptosis in cultured cells
@en
P2093
Hiroshi Mori
Kazuchika Nishitsuji
Kenichi Ishibashi
Mary P Lambert
Rie Teraoka
Takami Tomiyama
William L Klein
P2860
P304
P356
10.2353/AJPATH.2009.080480
P407
P50
P577
2009-01-22T00:00:00Z