TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
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The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomesProgranulin: at the interface of neurodegenerative and metabolic diseasesHippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the LiteratureLysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106BTMEM106B expression is reduced in Alzheimer's disease brainsRegulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.The widening spectrum of C9ORF72-related disease; genotype/phenotype correlations and potential modifiers of clinical phenotype.The TMEM106B locus and TDP-43 pathology in older persons without FTLDThe Spectrum of C9orf72-mediated Neurodegeneration and Amyotrophic Lateral Sclerosis.TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers.Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.Genetics of FTLD: overview and what else we can expect from genetic studies."New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).What we know about TMEM106B in neurodegeneration.Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death.TMEM106B: a strong FTLD disease modifier.TMEM106B and frontotemporal lobar degeneration: can over-expression tell us how reductions are beneficial?A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.TMEM106B haplotypes have distinct gene expression patterns in aged brain.The lysosomal function of progranulin, a guardian against neurodegenerationVariation in TMEM106B in chronic traumatic encephalopathy
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TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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TMEM106B p.T185S regulates TME ...... s for frontotemporal dementia.
@en
TMEM106B p.T185S regulates TME ...... s for frontotemporal dementia.
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TMEM106B p.T185S regulates TME ...... s for frontotemporal dementia.
@en
TMEM106B p.T185S regulates TME ...... s for frontotemporal dementia.
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TMEM106B p.T185S regulates TME ...... s for frontotemporal dementia.
@en
TMEM106B p.T185S regulates TME ...... s for frontotemporal dementia.
@nl
P2093
P2860
P50
P356
P1476
TMEM106B p.T185S regulates TME ...... s for frontotemporal dementia.
@en
P2093
Aleksandra Wojtas
Alexandra M Nicholson
Bradley F Boeve
Ging-Yuek R Hsiung
Giuliano Binetti
Ian R Mackenzie
Linda Rousseau
Matt C Baker
Monica Castanedes-Casey
Neill R Graff-Radford
P2860
P304
P356
10.1111/JNC.12329
P407
P50
P577
2013-07-01T00:00:00Z