Modulation of DNA methylation by a sesquiterpene lactone parthenolide. - Wikidata - awgldk - TriplyDB

Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

http://www.wikidata.org/entity/Q37168514

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Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells.The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.Epigenetic changes induced by curcumin and other natural compounds.The sesquiterpene lactone dehydroleucodine triggers senescence and apoptosis in association with accumulation of DNA damage markers.Augmenting antitumor immune responses with epigenetic modifying agents.Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS.Epigenetic mechanisms in anti-cancer actions of bioactive food components--the implications in cancer prevention NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres.Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis.Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones.Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells.Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.Reactivation of RASSF1A in breast cancer cells by curcumin Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor.Perspectives on natural product epigenetic modulators in chemical biology and medicine.Sesquiterpene lactones: adverse health effects and toxicity mechanisms.Targeting epigenetic mechanisms for clinical translation: enhancing the efficacy of tumor immunotherapies.The role of oxidative stress in anticancer activity of sesquiterpene lactones.Natural Compounds: DNA Methyltransferase Inhibitors in Oral Squamous Cell Carcinoma.Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors.Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line.The synergistic effect of SAHA and parthenolide in MDA-MB231 breast cancer cells.Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression Curcumin causes promoter hypomethylation and increased expression of FANCF gene in SiHa cell line.Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs.Sesquiterpene binding Gly-Leu-Ser/Lys-"co-adaptation pocket" to inhibit lung cancer cell epithelial-mesenchymal transition.Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach.The effect of carabrone on mitochondrial respiratory chain complexes in Gaeumannomyces graminis.The plant sesquiterpene lactone parthenoide inhibits Wnt/β-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1.Combined effects of anticancer drugs and new synthetic α-methylene-δ-lactones on MCF-7 cells.Discovery of Novel and Selective DNA Methyltransferase 1 Inhibitors by Pharmacophore and Docking-Based Virtual Screening

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Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

http://www.wikidata.org/entity/Q37168514

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 06 February 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

@en

Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

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type

label

Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

@en

Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

@nl

prefLabel

Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

@en

Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

@nl

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JPET.108.147934

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Journal of Pharmacology and Experimental Therapeutics

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Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

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Chenglong Li

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Christoph Plass

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Danilo Perrotti

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Deepak Bhasin

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Hongyan Wang

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James R Fuchs

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Jiejun Wu

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Jiuxia Pang

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Josephine Aimiuwu

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Kenneth K Chan

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P2860

Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms

HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

Comparative protein modelling by satisfaction of spatial restraints

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal

A semiempirical free energy force field with charge-based desolvation

DNA methylation and human disease

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505-514

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scholarly article

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10.1124/JPET.108.147934

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2

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329

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2009-02-06T00:00:00Z

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23989437

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19201992

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DNA methylation

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2672871

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