Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?
about
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traitsTwelve type 2 diabetes susceptibility loci identified through large-scale association analysisInsights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related TraitsInsights into obesity and diabetes at the intersection of mouse and human geneticsLost in translation: endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitusDoes disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes?Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetesNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskGenetics of type 2 diabetes: pathophysiologic and clinical relevanceSystems biology approach reveals genome to phenome correlation in type 2 diabetesConsumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians.Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis.Estimating insulin sensitivity and beta cell function: perspectives from the modern pandemics of obesity and type 2 diabetes.Importance of β-Catenin in glucose and energy homeostasis.Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program ParticipantsAssociation of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample.Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641, and insulin resistance: replication of a gene-nutrient interaction in 4 populations of different ancestries.Understanding the high prevalence of diabetes in U.S. south Asians compared with four racial/ethnic groups: the MASALA and MESA studiesImpact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.Current status of islet cell replacement and regeneration therapy.Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians.Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosisGene-carbohydrate and gene-fiber interactions and type 2 diabetes in diverse populations from the National Health and Nutrition Examination Surveys (NHANES) as part of the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) studyRole of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.Clinical translation of genetic predictors for type 2 diabetes.Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible arm that is dispensable in the mature hormoneThe human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three U.S. population cohorts.Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult populationEffects of rs7903146 variation in the Tcf7l2 gene in the lipid metabolism of three different populationsDifferential effects of prenatal and postnatal nutritional environment on ß-cell mass development and turnover in male and female ratsAssociation of physical activity with lower type 2 diabetes incidence is weaker among individuals at high genetic risk.Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets.Inflammation, metaflammation and immunometabolic disorders.TCF7L2 is a master regulator of insulin production and processing.Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects.p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients.
P2860
Q21132476-70CA41CD-1032-4C47-A672-DBE701DBA404Q24609915-2705F3F1-B7B0-4CA2-95EA-51AEB539C6D6Q26781353-3C08DD48-2706-46CC-BC8B-72F127E00E32Q26852866-8E0DD2BC-FA4D-42EE-86B8-04BA85BA2135Q26864403-4AF022B0-BF98-4530-B0C5-F7191EB5A547Q27026480-F3ED05AA-309D-49E7-AB59-D86945EEBD1DQ28117792-5C0CE1EA-870B-47EA-AF65-95BA9D3679CDQ28270700-638482A9-8D77-42D8-A81E-41045304DBDFQ28302158-F0B9191C-1335-431A-B011-9592E208E57EQ28484866-DCBF246D-5480-45A0-BD2E-4679D1ECD066Q30278722-FC0BA1B2-3F49-4546-821C-E7E02C4B8BC3Q30368908-FA6A332D-0F55-409F-8A0B-B944FEB7A40CQ30420533-478E7F28-4F53-4CEC-ABF3-FECCAE0F1D43Q30525250-9967A2FD-56F6-4A73-BA4C-98CE8D1C1B22Q30708887-7A051406-460F-4F5D-9752-D3A1824B50E0Q33494963-A29E57FD-78D7-4626-902D-C3881ECF4942Q33556613-84689917-2B79-4D8D-BF16-9FD486215221Q33556619-16A89652-358B-4909-A41E-B441D7C7ED9DQ33631377-BF194AB8-CD41-43CB-ACD4-3A30FC0C1080Q33646626-C0584271-D8D9-4E6A-AA13-A7F2C5EFFFDFQ33646698-18BAE226-F1F1-4DB8-A2E7-33CC3C8B4C2EQ33738705-45F1C465-4DD6-4120-B8EB-C8305249D43AQ33803517-3CF388AF-A96C-4B04-8026-CBFB37DFECE9Q33851293-487F9453-26D9-42D1-BAAF-9C73C8C78F9EQ33891047-64651769-B5F2-4754-85A5-BA7C2B9CF778Q33936173-53FCD743-CF29-4646-BD4E-F0C4A167DA20Q33993695-B6D190FD-1798-4C1D-9591-7BDD7D54930BQ34124681-8B6A2F5D-CE85-43D1-9D9A-717F7AF22827Q34155456-DFBCE6BE-394C-4CB8-8ED9-C5ADE3A27644Q34192894-BB6907DE-D15D-4F92-B37C-723E654361ABQ34206098-042A9909-4C6A-40BD-AB10-BCE8E9624153Q34237374-74134D5D-77F9-41BB-8C91-7167DAA2E978Q34391568-2C3B001F-232F-49E3-BCD2-612BA1700666Q34392719-07C985B3-A53A-462C-9711-0F47B9A406E9Q34459198-B5993BD1-FCDD-4F20-88F1-E22059503F46Q34464568-D2AB95BF-95D8-4B32-94B3-3A14978C5530Q34550852-EF62C816-E9D7-41D7-82F9-D075CBC6DEBDQ34555421-ADEF69F5-1A09-4957-9A5B-0609F9A7D1B1Q34622510-20494B4F-D1CE-4980-8BB1-CF61AA9E91E4Q34800964-6CE1576E-1DB2-4129-A629-888F5B26E922
P2860
Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Newly identified loci highligh ...... the insulin resistance genes?
@en
Newly identified loci highligh ...... the insulin resistance genes?
@nl
type
label
Newly identified loci highligh ...... the insulin resistance genes?
@en
Newly identified loci highligh ...... the insulin resistance genes?
@nl
prefLabel
Newly identified loci highligh ...... the insulin resistance genes?
@en
Newly identified loci highligh ...... the insulin resistance genes?
@nl
P1433
P1476
Newly identified loci highligh ...... the insulin resistance genes?
@en
P2093
J C Florez
P2888
P304
P356
10.1007/S00125-008-1025-9
P577
2008-05-27T00:00:00Z