Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.
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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB betaImpaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant miceMyeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistanceShc and CEACAM1 interact to regulate the mitogenic action of insulinDevelopment of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistanceOverexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistanceIslet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemiaInsulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiationEffects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistanceElevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant settingPositional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in miceA novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis.Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblastsSpatial compartmentalization of signal transduction in insulin action.Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K miceDivergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neuronsMice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cellsInsulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissueRestoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action.Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas.PTEN expression causes feedback upregulation of insulin receptor substrate 2Interactions between insulin resistance and insulin secretion in the development of glucose intolerance.Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3betaPTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.Glucose infusion in mice: a new model to induce beta-cell replication.Genetic modifiers of atherosclerosis in miceTargeted disruption of pancreatic-derived factor (PANDER, FAM3B) impairs pancreatic beta-cell functionInsulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.Genetic manipulation of insulin signaling, action and secretion in mice. Insights into glucose homeostasis and pathogenesis of type 2 diabetes.The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cellsSpontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele.Insulin receptor substrate polymorphisms and type 2 diabetes mellitus.Approach to assessing determinants of glucose homeostasis in the conscious mouseTissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice.Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthJNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling.New insights into insulin resistance pathophysiology: how it affects glucose and lipid metabolism.The A2b adenosine receptor modulates glucose homeostasis and obesity
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P2860
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2000
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Tissue-specific insulin resist ...... in receptor, IRS-1, and IRS-2.
@en
Tissue-specific insulin resist ...... in receptor, IRS-1, and IRS-2.
@nl
type
label
Tissue-specific insulin resist ...... in receptor, IRS-1, and IRS-2.
@en
Tissue-specific insulin resist ...... in receptor, IRS-1, and IRS-2.
@nl
prefLabel
Tissue-specific insulin resist ...... in receptor, IRS-1, and IRS-2.
@en
Tissue-specific insulin resist ...... in receptor, IRS-1, and IRS-2.
@nl
P2093
P2860
P356
P1476
Tissue-specific insulin resist ...... in receptor, IRS-1, and IRS-2.
@en
P2093
P2860
P304
P356
10.1172/JCI7917
P407
P577
2000-01-01T00:00:00Z