Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. - Wikidata - awgldk - TriplyDB

Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

http://www.wikidata.org/entity/Q37183404

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Akt and mTOR in B Cell Activation and Differentiation B cell receptor editing in tolerance and autoimmunity Signaling by the phosphoinositide 3-kinase family in immune cells Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.Pathways leading to an immunological disease: systemic lupus erythematosus.Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies Central B-cell tolerance: where selection begins.FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.The development of mature B lymphocytes requires the combined function of CD19 and the p110δ subunit of PI3K Enforced expression of the apoptosis inhibitor Bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanism Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape A new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Igκ gene expression PI3Ks in lymphocyte signaling and development The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Reduced receptor editing in lupus-prone MRL/lpr mice Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice.Receptor editing and genetic variability in human autoreactive B cells.PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice Regulation of VH replacement by B cell receptor-mediated signaling in human immature B cells Critical roles of the PI3K/Akt signaling pathway in T cell development Mechanisms controlling expression of the RAG locus during lymphocyte development.Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling.Fine tuning the immune response with PI3K.Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire.Tolerance checkpoints in B-cell development: Johnny B good.Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity?Control systems and decision making for antibody production.Allelic exclusion of immunoglobulin genes: models and mechanisms.Role of PI3K in the generation and survival of B cells.Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis.B lymphocytes: development, tolerance, and their role in autoimmunity-focus on systemic lupus erythematosus.The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.Mechanisms of central tolerance for B cells.Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia.

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Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

http://www.wikidata.org/entity/Q37183404

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on May 2007

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Basal B cell receptor-directed ...... tes B cell-positive selection.

@en

Basal B cell receptor-directed ...... tes B cell-positive selection.

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type

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Basal B cell receptor-directed ...... tes B cell-positive selection.

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Basal B cell receptor-directed ...... tes B cell-positive selection.

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prefLabel

Basal B cell receptor-directed ...... tes B cell-positive selection.

@en

Basal B cell receptor-directed ...... tes B cell-positive selection.

@nl

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JIMMUNOL.178.10.6332

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Journal of Immunology

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Basal B cell receptor-directed ...... otes B cell-positive selection

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P2093

Bao Duong

http://www.w3.org/2001/XMLSchema#string

Djemel Aït-Azzouzene

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José Luis Vela

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Kamal Puri

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Laurent Verkoczy

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Patrick Skog

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P2860

T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression

CD19 is functionally and physically associated with surface immunoglobulin

Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.

Xid-like phenotypes: a B cell signalosome takes shape

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex

Phosphoinositide 3-kinase: diverse roles in immune cell activation

Cellular maturation defects in Bruton's tyrosine kinase-deficient immature B cells are amplified by premature B cell receptor expression and reduced by receptor editing

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop

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6332-6341

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10.4049/JIMMUNOL.178.10.6332

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3777394

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