Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
about
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein responseThe p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complexFBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascadeIncreased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinaseThe PTEN/PI3K pathway governs normal vascular development and tumor angiogenesisAPS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytesTopographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiationInsulin receptor signaling in normal and insulin-resistant statesPhosphoinositides: tiny lipids with giant impact on cell regulationGlucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetesEssential role for the p110delta phosphoinositide 3-kinase in the allergic responseReduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetesExpression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patientsThe N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axisPositive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signalingp85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiationActivation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscleDirect positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation.Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangementN-terminal domains of the class ia phosphoinositide 3-kinase regulatory subunit play a role in cytoskeletal but not mitogenic signaling.Nineteenth-century veterinary medicine as an urban profession.Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.Apelin is necessary for the maintenance of insulin sensitivity.Microgravity-Induced Transcriptome Adaptation in Mouse Paraspinal longissimus dorsi Muscle Highlights Insulin Resistance-Linked Genes.Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages.Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determinationInterleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha.Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinaseComplete antithrombin deficiency in mice results in embryonic lethality.Role of phosphatidylinositol 3-kinase in friend spleen focus-forming virus-induced erythroid disease.Insights into insulin resistance and type 2 diabetes from knockout mouse models.PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genesIncreased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- miceSirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
P2860
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P2860
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
description
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 1999
@ast
im Februar 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/02/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/02/01)
@nl
наукова стаття, опублікована в лютому 1999
@uk
name
Increased insulin sensitivity ...... t of phosphoinositide 3-kinase
@ast
Increased insulin sensitivity ...... t of phosphoinositide 3-kinase
@en
Increased insulin sensitivity ...... t of phosphoinositide 3-kinase
@nl
type
label
Increased insulin sensitivity ...... t of phosphoinositide 3-kinase
@ast
Increased insulin sensitivity ...... t of phosphoinositide 3-kinase
@en
Increased insulin sensitivity ...... t of phosphoinositide 3-kinase
@nl
prefLabel
Increased insulin sensitivity ...... t of phosphoinositide 3-kinase
@ast
Increased insulin sensitivity ...... t of phosphoinositide 3-kinase
@en
Increased insulin sensitivity ...... t of phosphoinositide 3-kinase
@nl
P2093
P921
P3181
P356
P1433
P1476
Increased insulin sensitivity ...... t of phosphoinositide 3-kinase
@en
P2093
H. Minoura
H. Nakajima
H. Sekihara
J. C. Barrett
K. Murakami
P2888
P304
P3181
P356
10.1038/6023
P407
P577
1999-02-01T00:00:00Z
P5875
P6179
1028481506