about
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactorTargeting the mTOR kinase domain: the second generation of mTOR inhibitorsToll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responsesRegulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphateBCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathwayPhosphoinositides: tiny lipids with giant impact on cell regulationMolecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapseSignaling by the phosphoinositide 3-kinase family in immune cellsAnti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathwayRas is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gammaPI3K and cancer: lessons, challenges and opportunitiesTargeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitorISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes.Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.OX40 induces CCL20 expression in the context of antigen stimulation: an expanding role of co-stimulatory molecules in chemotaxis.The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunityS100B Protein, A Damage-Associated Molecular Pattern Protein in the Brain and Heart, and Beyond.Too much of a good thing: immunodeficiency due to hyperactive PI3K signalingPhosphatidylinositol 3-kinase: the oncoprotein.Lipid signaling in T-cell development and functionTwo hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.Molecular underpinning of B-cell anergy.Combination of temsirolimus (CCI-779) with chemoradiation in newly diagnosed glioblastoma multiforme (GBM) (NCCTG trial N027D) is associated with increased infectious risksT regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.Accumulation of splice variants and transcripts in response to PI3K inhibition in T cells.p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway.Sjögren's syndrome: studying the disease in mice.Mouse Models of Primary Sjogren's Syndrome.PI3Ks in lymphocyte signaling and developmentReversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes.Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Asymmetric Cell Division in T Lymphocyte Fate Diversification.Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advancesPhospholipids: "greasing the wheels" of humoral immunity
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Fine tuning the immune response with PI3K.
@en
Fine tuning the immune response with PI3K.
@nl
type
label
Fine tuning the immune response with PI3K.
@en
Fine tuning the immune response with PI3K.
@nl
prefLabel
Fine tuning the immune response with PI3K.
@en
Fine tuning the immune response with PI3K.
@nl
P2860
P1476
Fine tuning the immune response with PI3K.
@en
P2093
David A Fruman
Georges Bismuth
P2860
P304
P356
10.1111/J.1600-065X.2008.00750.X
P577
2009-03-01T00:00:00Z