Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation
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Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activationThe magic of bicelles lights up membrane protein structureAnnular anionic lipids stabilize the integrin αIIbβ3 transmembrane complex.The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.Structure of an integrin IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activationMembrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin ActivationBasic amino-acid side chains regulate transmembrane integrin signallingTM9 family proteins control surface targeting of glycine-rich transmembrane domainsConstruction of covalent membrane protein complexes and high-throughput selection of membrane mimics.New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering.Consensus motif for integrin transmembrane helix associationIntegrin αII b tail distal of GFFKR participates in inside-out αII b β3 activation.Structural basis of transmembrane domain interactions in integrin signaling.Intermolecular transmembrane domain interactions activate integrin αIIbβ3.The final steps of integrin activation: the end gamePlatelets and cancer: a casual or causal relationship: revisited.Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signalingMultiscale simulations suggest a mechanism for integrin inside-out activation.Reconstruction of integrin activation.Talin activates integrins by altering the topology of the β transmembrane domainThe Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological LigandThree-Dimensional Structures of Full-Length, Membrane-Embedded Human α(IIb)β(3) Integrin ComplexesDirectly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering.In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signalingRegulation of integrin activity and signallingKindling the flame of integrin activation and function with kindlinsImplications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.Recent advances in the understanding of the molecular mechanisms regulating platelet integrin αIIbβ3 activation.Molecular mechanism of inside-out integrin regulationPlatelet signaling-a primer.Integrin bi-directional signaling across the plasma membrane.Mechanisms of talin-dependent integrin signaling and crosstalkTalin and kindlin: the one-two punch in integrin activation.Platelet "first responders" in wound response, cancer, and metastasis.Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activationA Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors.Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanismTalin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations.Characterization of a novel focal adhesion kinase inhibitor in human platelets.Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α-granules.
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Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 13 February 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Interactions of platelet integ ...... ir role in integrin activation
@en
Interactions of platelet integ ...... r role in integrin activation.
@nl
type
label
Interactions of platelet integ ...... ir role in integrin activation
@en
Interactions of platelet integ ...... r role in integrin activation.
@nl
prefLabel
Interactions of platelet integ ...... ir role in integrin activation
@en
Interactions of platelet integ ...... r role in integrin activation.
@nl
P2093
P2860
P1433
P1476
Interactions of platelet integ ...... ir role in integrin activation
@en
P2093
Chungho Kim
Mark H Ginsberg
Tobias S Ulmer
Tong-Lay Lau
P2860
P304
P356
10.1182/BLOOD-2008-10-186551
P407
P577
2009-02-13T00:00:00Z