Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling.
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SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide productionNuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complexlin-12 Notch functions in the adult nervous system of C. elegans.Caenorhabditis elegans as a model organism to study APP functionAnalysis of regulatory protease sequences identified through bioinformatic data mining of the Schistosoma mansoni genomePresenilin function in Caenorhabditis elegansMice lacking both presenilin genes exhibit early embryonic patterning defectsThe glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegansHigh-throughput isolation of Caenorhabditis elegans deletion mutantsMutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegansFunction and dysfunction of the presenilinsAPH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryosTherapeutic target discovery using Caenorhabditis elegans.Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition.The Notch signalling system: recent insights into the complexity of a conserved pathwayEvidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACESeparation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans.spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegansPresenilin function and gamma-secretase activity.Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system.The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins.Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.Identification and characterization of presenilin-independent Notch signaling.Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines.A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells.A network model for the specification of vulval precursor cells and cell fusion control in Caenorhabditis elegansPresenilin is required for proper morphology and function of neurons in C. elegans.Screening for presenilin inhibitors using the free-living nematode, Caenorhabditis elegans.HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans.
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Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1999
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Reverse genetic analysis of Ca ...... -1 in Notch-pathway signaling.
@en
Reverse genetic analysis of Ca ...... -1 in Notch-pathway signaling.
@nl
type
label
Reverse genetic analysis of Ca ...... -1 in Notch-pathway signaling.
@en
Reverse genetic analysis of Ca ...... -1 in Notch-pathway signaling.
@nl
prefLabel
Reverse genetic analysis of Ca ...... -1 in Notch-pathway signaling.
@en
Reverse genetic analysis of Ca ...... -1 in Notch-pathway signaling.
@nl
P2093
P2860
P356
P1476
Reverse genetic analysis of Ca ...... -1 in Notch-pathway signaling.
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.5.2497
P407
P577
1999-03-01T00:00:00Z