A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts
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C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cellsDesigned, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitroFunction through synthesis-informed designMolecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivityThe role of kinin receptors in preventing neuroinflammation and its clinical severity during experimental autoimmune encephalomyelitis in miceTotal synthesis of bryostatin 9Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone coreTranslating Nature's Library: The Bryostatins and Function-Oriented SynthesisPolyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthaseToward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopyConformation-activity relationships of polyketide natural products.Studies on the regio- and diastereo-selective epoxidation of daphnanes and tiglianes."Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo.Identification of the PS1 Thr147Ile Variant in a Family with Very Early Onset Dementia and Expressive Aphasia.The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene.Mechanistic and computational studies of exocyclic stereocontrol in the synthesis of bryostatin-like cis-2,6-disubstituted 4-alkylidenetetrahydropyrans by Prins cyclization.Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbersSimplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death.Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities.The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's diseaseBryostatin and its synthetic analog, picolog rescue dermal fibroblasts from prolonged stress and contribute to survival and rejuvenation of human skin equivalents.Protein kinase C is essential for viability of the rice blast fungus Magnaporthe oryzaeUsing surrogates to bypass missing catalytic components.Protein kinase C-regulated aβ production and clearance.Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes.Induction of nerve growth factor by phorbol 12-myristate 13-acetate is dependent upon the mitogen activated protein kinase pathway.Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors†Dedicated to Max Malacria, a friend and scholar whose science and creative contributions to step-economical synthesis have inspired usBioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry
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P2860
A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 20 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A cellular model of Alzheimer' ...... mality on cultured fibroblasts
@en
A cellular model of Alzheimer' ...... ality on cultured fibroblasts.
@nl
type
label
A cellular model of Alzheimer' ...... mality on cultured fibroblasts
@en
A cellular model of Alzheimer' ...... ality on cultured fibroblasts.
@nl
prefLabel
A cellular model of Alzheimer' ...... mality on cultured fibroblasts
@en
A cellular model of Alzheimer' ...... ality on cultured fibroblasts.
@nl
P2093
P2860
P1476
A cellular model of Alzheimer' ...... mality on cultured fibroblasts
@en
P2093
Daniel L Alkon
Paul A Wender
Tapan K Khan
Thomas J Nelson
Vishal A Verma
P2860
P304
P356
10.1016/J.NBD.2009.02.003
P577
2009-02-20T00:00:00Z