Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet.
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Genetically modified mouse models for the study of nonalcoholic fatty liver diseaseFatty liver diseases, bile acids, and FXRAgeing Fxr deficient mice develop increased energy expenditure, improved glucose control and liver damage resembling NASHmiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in miceLDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease.Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in miceObeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats.Tissue specific induction of p62/Sqstm1 by farnesoid X receptor.Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategiesTissue-specific function of farnesoid X receptor in liver and intestineImpaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver diseaseFXR and liver carcinogenesisStrategies, models and biomarkers in experimental non-alcoholic fatty liver disease researchBile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease.Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway.Farnesoid X Receptor Activation Attenuates Intestinal Ischemia Reperfusion Injury in RatsDysregulation of bile acid homeostasis in parenteral nutrition mouse modelNADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.Review article: the emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease.Molecular Interactions between NAFLD and Xenobiotic Metabolism.Comparative analysis of temporal and dose-dependent TCDD-elicited gene expression in human, mouse, and rat primary hepatocytesBile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease.Silymarin Ameliorates Metabolic Dysfunction Associated with Diet-Induced Obesity via Activation of Farnesyl X Receptor.Farnesoid X receptor-Acting through bile acids to treat metabolic disorders.Bile acid receptors in non-alcoholic fatty liver disease.Farnesoid x receptor agonists: what they are and how they might be used in treating liver disease.Non-alcoholic Fatty liver disease: the bile Acid-activated farnesoid x receptor as an emerging treatment target.Role of microRNAs in the regulation of drug metabolism and disposition genes in diabetes and liver disease.Intrahepatic cholestasis in common chronic liver diseases.GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells.Recent advances in mouse models of obesity- and nonalcoholic steatohepatitis-associated hepatocarcinogenesis.The pharmacological management of NAFLD in children and adolescents.Review article: new treatments in non-alcoholic fatty liver disease.The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis.Changes in drug transport and metabolism and their clinical implications in non-alcoholic fatty liver disease.Nuclear receptors and nonalcoholic fatty liver disease.An estrogen receptor β-selective agonist inhibits non-alcoholic steatohepatitis in preclinical models by regulating bile acid and xenobiotic receptors.The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
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P2860
Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Farnesoid X receptor deficienc ...... kout mice fed a high-fat diet.
@en
Farnesoid X receptor deficienc ...... kout mice fed a high-fat diet.
@nl
type
label
Farnesoid X receptor deficienc ...... kout mice fed a high-fat diet.
@en
Farnesoid X receptor deficienc ...... kout mice fed a high-fat diet.
@nl
prefLabel
Farnesoid X receptor deficienc ...... kout mice fed a high-fat diet.
@en
Farnesoid X receptor deficienc ...... kout mice fed a high-fat diet.
@nl
P2093
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P1476
Farnesoid X receptor deficienc ...... kout mice fed a high-fat diet.
@en
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Grace L Guo
James P Luyendyk
Ossama Tawfik
P2860
P304
P356
10.1124/JPET.108.144600
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P577
2008-10-23T00:00:00Z