Identification of a chemical tool for the orphan nuclear receptor FXR. - Wikidata - awgldk - TriplyDB

Identification of a chemical tool for the orphan nuclear receptor FXR.

Identification of a chemical tool for the orphan nuclear receptor FXR.

http://www.wikidata.org/entity/Q31431724

about

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR FXR signaling in the enterohepatic system Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation Bile acid nuclear receptor FXR and digestive system diseases Role of farnesoid X receptor and bile acids in alcoholic liver disease Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element Farnesoid X receptor regulates bile acid-amino acid conjugation MAFG is a transcriptional repressor of bile acid synthesis and metabolism Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor FXR-mediated regulation of eNOS expression in vascular endothelial cells The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice Farnesoid X Receptor an Emerging Target to Combat Obesity.Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors.LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor.Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.Clinical application of transcriptional activators of bile salt transporters.Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro.The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway.Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner.Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor.Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism.Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance.Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism.Tissue specific induction of p62/Sqstm1 by farnesoid X receptor.

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P2860

Identification of a chemical tool for the orphan nuclear receptor FXR.

http://www.wikidata.org/entity/Q31431724

description

2000 nî lūn-bûn

@nan

2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի օգոստոսին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

@zh-hk

2000年論文

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2000年論文

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2000年论文

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name

Identification of a chemical tool for the orphan nuclear receptor FXR.

@ast

Identification of a chemical tool for the orphan nuclear receptor FXR.

@en

type

label

Identification of a chemical tool for the orphan nuclear receptor FXR.

@ast

Identification of a chemical tool for the orphan nuclear receptor FXR.

@en

prefLabel

Identification of a chemical tool for the orphan nuclear receptor FXR.

@ast

Identification of a chemical tool for the orphan nuclear receptor FXR.

@en

P1433

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Journal of Medicinal Chemistry

P1476

Identification of a chemical tool for the orphan nuclear receptor FXR.

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P2093

Chandra G

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Creech KL

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Fivush AM

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Haffner CD

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Jones SA

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Lewis MC

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Maloney PR

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Moore LB

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Parks DJ

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Plunket KD

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2971-2974

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scholarly article

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10.1021/JM0002127

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16

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