The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
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Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartmentAn atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitinationThe ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradationNumb activates the E3 ligase Itch to control Gli1 function through a novel degradation signalUbiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppressionSCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activityA novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinomaThe F-box protein FBXO45 promotes the proteasome-dependent degradation of p73UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor geneThe PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cellsA comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome systemThe ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survivalLys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activitySelective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMTAn emerging model for BAP1's role in regulating cell cycle progressionRegulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2Tissue- and Serum-Associated Biomarkers of Hepatocellular CarcinomaRole of Natural Radiosensitizers and Cancer Cell Radioresistance: An UpdateNeuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosisRoquin--a multifunctional regulator of immune homeostasisThe role of targeted protein degradation in early neural developmentTargeting the ubiquitin pathway for cancer treatmentNEDD4: a promising target for cancer therapyFunctional diversity and structural disorder in the human ubiquitination pathwayA Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination ActivitiesRecognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitinationA Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function ScreenMechanism of ubiquitin ligation and lysine prioritization by a HECT E3Systematic approaches to identify E3 ligase substratesNedd4 E3 ubiquitin ligase promotes cell proliferation and autophagyDissecting the expression landscape of RNA-binding proteins in human cancersActivation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnoverThe E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesisEzrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activityBRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300.The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.Animal HECT ubiquitin ligases: evolution and functional implications.Smurf1-mediated axin ubiquitination requires Smurf1 C2 domain and is cell cycle-dependentWP1130 increases cisplatin sensitivity through inhibition of usp9x in estrogen receptor-negative breast cancer cells.
P2860
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P2860
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
@en
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
@nl
type
label
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
@en
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
@nl
prefLabel
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
@en
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
@nl
P50
P1433
P1476
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
@en
P2093
Gerry Melino
P356
10.1016/J.CCR.2008.06.001
P577
2008-07-01T00:00:00Z