The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins.
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Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functionsMediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiationGenetic Cross-Talk During Head Development in DrosophilaThe Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee.The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domainA role for Groucho tetramerization in transcriptional repressionDrosophila melanogaster casein kinase II interacts with and phosphorylates the basic helix-loop-helix proteins m5, m7, and m8 derived from the Enhancer of split complex.Blueprint for a high-performance biomaterial: full-length spider dragline silk genesThe Notch target E(spl)mδ is a muscle-specific gene involved in methylmercury toxicity in motor neuron developmentPervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAsConservation and function of the transcriptional regulatory protein RuntDrosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression.Senseless acts as a binary switch during sensory organ precursor selection.Evolution of a genomic regulatory domain: the role of gene co-option and gene duplication in the Enhancer of split complex.A conserved motif in goosecoid mediates groucho-dependent repression in Drosophila embryos.Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus.HES-1 repression of differentiation and proliferation in PC12 cells: role for the helix 3-helix 4 domain in transcription repression.A genetic analysis of the Drosophila closely linked interacting genes bulge, argos and soba.Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis.Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins.A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing.Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling.The bHLH factors extramacrochaetae and daughterless control cell cycle in Drosophila imaginal discs through the transcriptional regulation of the Cdc25 phosphatase string.Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed.The Ser/Thr phosphatase PP2A regulatory subunit widerborst inhibits notch signaling.JAK/Stat signaling regulates heart precursor diversification in DrosophilaNew insights into the Orange domain of E(spl)-M8, and the roles of the C-terminal domain in autoinhibition and Groucho recruitmentOrigin and evolution of the enhancer of split complex.Gfi/Pag-3/senseless zinc finger proteins: a unifying theme?In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters.Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis.Phylogenetic footprinting analysis in the upstream regulatory regions of the Drosophila enhancer of split genes.Drosophila evolution challenges postulated redundancy in the E(spl) gene complex.The transcriptional corepressor SMRTER influences both Notch and ecdysone signaling during Drosophila developmentConcomitant requirement for Notch and Jak/Stat signaling during neuro-epithelial differentiation in the Drosophila optic lobeSpecificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repressionA chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression.Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk.A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system.
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P2860
The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The Enhancer of split [E
@nl
The Enhancer of split [E(spl)] ...... ent helix-loop-helix proteins.
@en
type
label
The Enhancer of split [E
@nl
The Enhancer of split [E(spl)] ...... ent helix-loop-helix proteins.
@en
prefLabel
The Enhancer of split [E
@nl
The Enhancer of split [E(spl)] ...... ent helix-loop-helix proteins.
@en
P2860
P356
P1476
The Enhancer of split [E(spl)] ...... ent helix-loop-helix proteins.
@en
P2093
C Delidakis
S Artavanis-Tsakonas
P2860
P304
P356
10.1073/PNAS.89.18.8731
P407
P577
1992-09-01T00:00:00Z