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Population-based mechanistic prediction of oral drug absorption

Population-based mechanistic prediction of oral drug absorption

http://www.wikidata.org/entity/Q37214520

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ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption.Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification Utility of physiologically based absorption modeling in implementing Quality by Design in drug development A comparative evaluation of models to predict human intestinal metabolism from nonclinical data.Practical anticipation of human efficacious doses and pharmacokinetics using in vitro and preclinical in vivo data.Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1-Related Variability in Pharmacodynamics of Rosuvastatin.Population pharmacokinetics and clinical response for artemether-lumefantrine in pregnant and nonpregnant women with uncomplicated Plasmodium falciparum malaria in Tanzania.Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.Midazolam pharmacokinetics in morbidly obese patients following semi-simultaneous oral and intravenous administration: a comparison with healthy volunteers.A physiologically based pharmacokinetic model of the minipig: data compilation and model implementation.Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates.Mathematical Models to Explore Potential Effects of Supersaturation and Precipitation on Oral Bioavailability of Poorly Soluble Drugs.A physiologically based pharmacokinetic drug-disease model to predict carvedilol exposure in adult and paediatric heart failure patients by incorporating pathophysiological changes in hepatic and renal blood flows Comparison of Deconvolution-Based and Absorption Modeling IVIVC for Extended Release Formulations of a BCS III Drug Development Candidate.The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery.Trends in oral drug bioavailability following bariatric surgery: examining the variable extent of impact on exposure of different drug classes.Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1-OH-midazolam in morbidly obese and weight loss surgery patients.Evaluating a physiologically based pharmacokinetic model for predicting the pharmacokinetics of midazolam in Chinese after oral administration.Quantitative prediction and clinical evaluation of an unexplored herb-drug interaction mechanism in healthy volunteers.Dose selection based on physiologically based pharmacokinetic (PBPK) approaches.Application of physiologically based pharmacokinetic modeling in predicting drug-drug interactions for sarpogrelate hydrochloride in humans Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children.A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporine Fixed-dose combination orally disintegrating tablets to treat cardiovascular disease: formulation, in vitro characterization and physiologically based pharmacokinetic modeling to assess bioavailability.Gastric emptying of non-disintegrating solid drug delivery systems in fasted state: relevance to drug dissolution.Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review.An update on computational oral absorption simulation.Modeling and predicting drug pharmacokinetics in patients with renal impairment.Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology.Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption.Animal models of toxicology testing: the role of pigs.Experimental models for predicting drug absorption and metabolism.Coupling biorelevant dissolution methods with physiologically based pharmacokinetic modelling to forecast in-vivo performance of solid oral dosage forms.Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices.Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective.Continuous Intestinal Absorption Model Based on the Convection-Diffusion Equation.Physiologically based pharmacokinetic-pharmacodynamic modeling to predict concentrations and actions of sodium-dependent glucose transporter 2 inhibitor canagliflozin in human intestines and renal tubules.Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models.

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Population-based mechanistic prediction of oral drug absorption

http://www.wikidata.org/entity/Q37214520

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 21 April 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

@da

vědecký článek

@cs

name

Population-based mechanistic prediction of oral drug absorption

@en

Population-based mechanistic prediction of oral drug absorption.

@nl

type

label

Population-based mechanistic prediction of oral drug absorption

@en

Population-based mechanistic prediction of oral drug absorption.

@nl

prefLabel

Population-based mechanistic prediction of oral drug absorption

@en

Population-based mechanistic prediction of oral drug absorption.

@nl

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S12248-009-9099-Y

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The AAPS Journal

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Population-based mechanistic prediction of oral drug absorption

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Amin Rostami-Hodjegan

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David Turner

http://www.w3.org/2001/XMLSchema#string

Geoffrey Tucker

http://www.w3.org/2001/XMLSchema#string

Jiansong Yang

http://www.w3.org/2001/XMLSchema#string

Masoud Jamei

http://www.w3.org/2001/XMLSchema#string

P2860

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

The Simcyp population-based ADME simulator

General solution for diffusion-controlled dissolution of spherical particles. 2. Evaluation of experimental data.

Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging.

Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability.

Saturable small intestinal drug absorption in humans: modeling and interpretation of cefatrizine data.

Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells.

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s12248-009-9099-y

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225-237

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scholarly article

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10.1208/S12248-009-9099-Y

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2

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11

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Sebastian Polak

Sibylle Neuhoff

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2009-04-21T00:00:00Z

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24312662

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1034493508

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19381840

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2691459

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