Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs? - Wikidata - awgldk - TriplyDB

Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?

Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?

http://www.wikidata.org/entity/Q37974113

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Recent Advances in Development and Application of Physiologically-Based Pharmacokinetic (PBPK) Models: a Transition from Academic Curiosity to Regulatory Acceptance Anesthesia and Monitoring in Small Laboratory Mammals Used in Anesthesiology, Respiratory and Critical Care Research: A Systematic Review on the Current Reporting in Top-10 Impact Factor Ranked Journals Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity Challenges of using in vitro data for modeling P-glycoprotein efflux in the blood-brain barrier.Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: a review of the data and identification of knowledge gaps.The simcyp population based simulator: architecture, implementation, and quality assurance.Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.A physiome interoperability roadmap for personalized drug development.Quantitative Systems Pharmacology: A Framework for Context.Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approach Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology.Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption.Predicting drug-drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach.Mathematical modeling analysis of intratumoral disposition of anticancer agents and drug delivery systems.In vitro-in vivo correlations: general concepts, methodologies and regulatory applications.Physiologically based pharmacokinetic models of small molecules and therapeutic antibodies: a mini-review on fundamental concepts and applications.Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions.Assessment of DCE-MRI parameters for brain tumors through implementation of physiologically-based pharmacokinetic model approaches for Gd-DOTA.Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach.Prediction of drug-drug interaction potential using physiologically based pharmacokinetic modeling.Simultaneous and comprehensive in vivo analysis of cytochrome P450 activity by using a cocktail approach in rats.In silico (computed) modelling of doses and dosing regimens associated with morphine levels above international legal driving limits.Physiologically based pharmacokinetic models for the optimization of antiretroviral therapy: recent progress and future perspective An introduction to systems toxicology

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Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?

http://www.wikidata.org/entity/Q37974113

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Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?

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Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?

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Biopharmaceutics and Drug Disposition

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Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?

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Bernard Walther

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François Bouzom

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Kathryn Ball

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Nathalie Perdaems

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Membrane transporters in drug development

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes.

A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance.

Physiological modeling to understand the impact of enzymes and transporters on drug and metabolite data and bioavailability estimates.

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: prediction of plasma concentration-time profiles in human from in vivo preclinical data by using the Wajima approach.

A physiological model for the estimation of the fraction dose absorbed in humans.

Predicting the impact of physiological and biochemical processes on oral drug bioavailability.

Prediction of human pharmacokinetics--gut-wall metabolism.

Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development.

Whole body pharmacokinetic models.

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55-71

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scholarly article

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10.1002/BDD.1767

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2

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33

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2012-01-26T00:00:00Z

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221732025

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22228149

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