New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.
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Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagyThe Role of the Membrane-Initiated Heat Shock Response in CancerHsp90: A New Player in DNA Repair?Heat shock proteins (HSPs) in the homeostasis of regulatory T cells (Tregs)Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signalingProtein interactions, post-translational modifications and topologies in human cells.Physiological regulation of Akt activity and stability.Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin AHSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible wayA Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer.Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way.Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cellsThe crossroads between cancer stem cells and aging.The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabineSynergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression.Inhibition of gastric tumor growth by a novel Hsp90 inhibitor.A novel therapeutic strategy for the treatment of glioma, combining chemical and molecular targeting of hsp90a.Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapiesHsp90, an unlikely ally in the war on cancer.A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation.Radioprotective effects of oral 17-dimethylaminoethylamino-17-demethoxygeldanamycin in mice: bone marrow and small intestine.Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes.Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases.HPLC method development, validation and impurity characterization for an antitumor Hsp90 inhibitor-PU-H71 (NSC 750424).Heat-shock protein 90 inhibitors as antitumor agents: a survey of the literature from 2005 to 2010.HSP90: chaperone-me-not.A network biology approach to understanding the importance of chameleon proteins in human physiology and pathology.TRAP1: a viable therapeutic target for future cancer treatments?β-Lapachone Induces NAD(P)H:Quinone Oxidoreductase-1- and Oxidative Stress-Dependent Heat Shock Protein 90 Cleavage and Inhibits Tumor Growth and Angiogenesis.Destabilizing RET in targeted treatment of thyroid cancers.Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target.Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.IP-FCM platform detects the existence and regulator-caused dissociation of components in naturally assembled HSP90 complex.5-Episinuleptolide acetate, a norcembranoidal diterpene from the formosan soft coral Sinularia sp., induces leukemia cell apoptosis through Hsp90 inhibition.Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cellsBIIB021: A novel inhibitor to heat shock protein 90-addicted oncology.Development of a Grp94 inhibitor.
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New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
New developments in Hsp90 inhi ...... erspective and more potential.
@en
New developments in Hsp90 inhi ...... erspective and more potential.
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type
label
New developments in Hsp90 inhi ...... erspective and more potential.
@en
New developments in Hsp90 inhi ...... erspective and more potential.
@nl
prefLabel
New developments in Hsp90 inhi ...... erspective and more potential.
@en
New developments in Hsp90 inhi ...... erspective and more potential.
@nl
P2093
P2860
P1476
New developments in Hsp90 inhi ...... perspective and more potential
@en
P2093
P2860
P356
10.1016/J.DRUP.2008.12.002
P577
2009-02-01T00:00:00Z