Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line
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Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemiaCalnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complexMicrosomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidationCharacterization of the biosynthesis of human immunodeficiency virus type 1 Env from infected T-cells and the effects of glucose trimming of Env on virion infectivity.ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart.Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins.Apolipoprotein B metabolism: tracer kinetics, models, and metabolic studies.Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core.Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availabilityIdentification of tropoelastin as a ligand for the 65-kD FK506-binding protein, FKBP65, in the secretory pathway.Endothelial cells synthesize and process apolipoprotein B.Amino acid sequences within the beta1 domain of human apolipoprotein B can mediate rapid intracellular degradation.Apolipoprotein B is synthesized in selected human non-hepatic cell lines but not processed into mature lipoprotein.Studies on degradative mechanisms mediating post-translational fragmentation of apolipoprotein B and the generation of the 70-kDa fragment.Intracellular translocation and stability of apolipoprotein B are inversely proportional to the length of the nascent polypeptide.The enzymatic and non-enzymatic roles of protein-disulfide isomerase in apolipoprotein B secretion.Apolipoprotein B is intracellularly associated with an ER-60 protease homologue in HepG2 cells.Folding of the amino-terminal domain of apolipoprotein B initiates microsomal triglyceride transfer protein-dependent lipid transfer to nascent very low density lipoprotein.Studies on intracellular translocation of apolipoprotein B in a permeabilized HepG2 system.Intracellular assembly and degradation of apolipoprotein B-100-containing lipoproteins in digitonin-permeabilized HEP G2 cells.Interactions between microsomal triglyceride transfer protein and apolipoprotein B within the endoplasmic reticulum in a heterologous expression system.The amino terminus of apolipoprotein B is necessary but not sufficient for microsomal triglyceride transfer protein responsiveness.Studies on the translocation of the amino terminus of apolipoprotein B into the endoplasmic reticulum.Role of lipid synthesis, chaperone proteins and proteasomes in the assembly and secretion of apoprotein B-containing lipoproteins from cultured liver cells.Chinese hamster ovary cells require the coexpression of microsomal triglyceride transfer protein and cholesterol 7alpha-hydroxylase for the assembly and secretion of apolipoprotein B-containing lipoproteins.One or more labile proteins regulate the stability of chimeric mRNAs containing the 3'-untranslated region of cholesterol-7alpha -hydroxylase mRNA.Degradation of apolipoprotein B in cultured rat hepatocytes occurs in a post-endoplasmic reticulum compartment.Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER.Coordinate regulation of lipogenesis, the assembly and secretion of apolipoprotein B-containing lipoproteins by sterol response element binding protein 1.Translocation-arrested apolipoprotein B evades proteasome degradation via a sterol-sensitive block in ubiquitin conjugation.Inhibition of secretion of truncated apolipoproteins B by monomethylethanolamine is independent of the length of the apolipoprotein.
P2860
Q24671906-FE156087-DDE1-40BE-AA3E-7A2B98BC20C9Q28269183-54802379-5F58-42E8-959B-B8C1D77BD465Q28590076-E1108CA9-CCEB-4F31-A68B-A7511EE705A4Q31510236-FA4AEEFD-2414-4E09-B3DB-F6BF41535D0CQ34563979-3269F5A9-15D4-4BE8-A594-8A0CAA3C6DD6Q34634838-20240687-9033-4F4A-BCAC-807A67C9628BQ34640735-CFC06BD2-EB53-4D8B-900F-D25CF200B729Q34713756-13F549FE-E91A-4BC2-847E-097C84436CEBQ35652901-F993369E-E6FB-439E-80FE-0B2F7AD801B9Q36254825-79AFF89C-262B-4B54-A34D-45780CC5CDE3Q36802939-32296A07-899E-4052-8BB3-B7E36A005FC5Q40622275-44537C80-52A2-4640-82EC-F96AEE0445A6Q40736669-E9B65BD7-0D16-498C-8A2E-2E973518AD2DQ40937167-E6238640-9BC2-4116-8567-639B0912EDD5Q40990890-9C00E6AB-8306-48E0-B999-70FC2D943B38Q41083698-01C55B3D-1268-4EAA-BDA4-AA0633D8C946Q41091831-05098EE1-399D-4B4C-9392-39F438678EF1Q41116286-4E4AE7BE-0FF6-491B-A5E2-9795ED586480Q41120970-FFD4445B-EF9B-4F9E-A6E0-889967BFACA0Q41126991-F9EA5648-694D-4D0C-8AA8-3B4D77993932Q41176498-3B5451C8-421D-4428-BC95-CEF50F7DE9E4Q41206198-D548D3CD-6EB0-472B-9A6F-12458715BD1CQ41357823-C9C9B3BA-D73A-433E-9057-0BD04CFF208BQ41464557-BABD9B82-3548-4B12-B8A6-C74DB58E0D39Q41616361-6CFEF9D8-3155-4A96-AC9C-AB2525FF8E8BQ41730138-00652D0B-E8F0-414A-89AB-8A0EB4BBFDCFQ41932310-FF56B163-597A-4C85-B2DC-9729F0AD7A9AQ44317091-08880E61-ECDD-44BC-8133-06128068FAA5Q44832057-7233DA82-49D0-48E3-A767-0D98E3782F2EQ46415806-88CC3013-68D7-43F6-B858-46CD46B06864Q52510446-654690D3-887C-41DF-AB0A-F5D5BD3DA963
P2860
Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Translocation of apolipoprotei ...... cked in a nonhepatic cell line
@en
Translocation of apolipoprotei ...... ked in a nonhepatic cell line.
@nl
type
label
Translocation of apolipoprotei ...... cked in a nonhepatic cell line
@en
Translocation of apolipoprotei ...... ked in a nonhepatic cell line.
@nl
prefLabel
Translocation of apolipoprotei ...... cked in a nonhepatic cell line
@en
Translocation of apolipoprotei ...... ked in a nonhepatic cell line.
@nl
P2093
P2860
P356
P1476
Translocation of apolipoprotei ...... cked in a nonhepatic cell line
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.19.9161
P407
P577
1992-10-01T00:00:00Z