Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine - Wikidata - awgldk - TriplyDB

Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

http://www.wikidata.org/entity/Q37226538

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Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.The short-lived African turquoise killifish: an emerging experimental model for ageing Can Peto's paradox be used as the null hypothesis to identify the role of evolution in natural resistance to cancer? A critical review Somatic mutations in aging, cancer and neurodegeneration Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations Intra-organ variation in age-related mutation accumulation in the mouse.Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans.Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster Somatic mutations, genome mosaicism, cancer and aging.Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging.Mutational fingerprints of aging.Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis.Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues.Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster.8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress Cellular stress response pathways and ageing: intricate molecular relationships Aging genomes: a necessary evil in the logic of life.Tissue-specific differences in the accumulation of sequence rearrangements with age.Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates.Age-related somatic mutations in the cancer genome Telomeres, aging and cancer: in search of a happy ending.Do DNA Double-Strand Breaks Drive Aging?Accurate quantification of more than 4000 mouse tissue proteins reveals minimal proteome changes during aging.Changes in DNA repair during aging.Evolution of a higher intracellular oxidizing environment in Caenorhabditis elegans under relaxed selection.Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis.Age-dependent accumulation of recombinant cells in the mouse pancreas revealed by in situ fluorescence imaging.Double-strand break repair by interchromosomal recombination: an in vivo repair mechanism utilized by multiple somatic tissues in mammals.Protein domain-level landscape of cancer-type-specific somatic mutations.No evidence of elevated germline mutation accumulation under oxidative stress in Caenorhabditis elegans.Genome dynamics and transcriptional deregulation in aging.De novo ChIP-seq analysis.Accumulation of Deleterious Passenger Mutations Is Associated with the Progression of Hepatocellular Carcinoma Stem cells from birth to death: The history and the future Inducing iPSCs to escape the dish.Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype.Arthroplasty Utilization in the United States is Predicted by Age-Specific Population Groups BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer

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Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

http://www.wikidata.org/entity/Q37226538

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on July 2000

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Distinct spectra of somatic mu ...... ouse heart and small intestine

@en

Distinct spectra of somatic mu ...... use heart and small intestine.

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type

label

Distinct spectra of somatic mu ...... ouse heart and small intestine

@en

Distinct spectra of somatic mu ...... use heart and small intestine.

@nl

prefLabel

Distinct spectra of somatic mu ...... ouse heart and small intestine

@en

Distinct spectra of somatic mu ...... use heart and small intestine.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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Distinct spectra of somatic mu ...... ouse heart and small intestine

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J A Gossen

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J Vijg

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M E Dollé

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P H Lohman

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W K Snyder

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P2860

Oxidative Decay of DNA

Instability and decay of the primary structure of DNA

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases

How aneuploidy affects metabolic control and causes cancer

Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice

Mutator phenotype of Werner syndrome is characterized by extensive deletions

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Deletion of Ku86 causes early onset of senescence in mice

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

Positional cloning of the Werner's syndrome gene

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