about
The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skinDifferent quaternary structures of human RECQ1 are associated with its dual enzymatic activityCloning of cDNA encoding a novel mouse DNA topoisomerase III (Topo IIIbeta) possessing negatively supercoiled DNA relaxing activity, whose message is highly expressed in the testisConstruction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3Mutations of a novel human RAD54 homologue, RAD54B, in primary cancerFunctional and physical interaction between WRN helicase and human replication protein AMutator pathways unleashed by epigenetic silencing in human cancerElevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.Nuclear structure in normal and Bloom syndrome cellsKu complex interacts with and stimulates the Werner proteinReplication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activityPotent inhibition of werner and bloom helicases by DNA minor groove binding drugsCharacterization of the human and mouse WRN 3'-->5' exonucleaseStructure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genesRegulation and localization of the Bloom syndrome protein in response to DNA damageA functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNADiverged nuclear localization of Werner helicase in human and mouse cellsp53 Modulates the exonuclease activity of Werner syndrome proteinThe Bloom's and Werner's syndrome proteins are DNA structure-specific helicasesWerner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activityStructural and functional analyses of disease-causing missense mutations in Bloom syndrome proteinStructural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrityHuman RECQL5 participates in the removal of endogenous DNA damageWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkStimulation of flap endonuclease-1 by the Bloom's syndrome proteinTelomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicasesIdentification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicasesRegulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylationWRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shorteningWerner syndrome protein interacts functionally with translesion DNA polymerasesThe Bloom's syndrome gene product is a 3'-5' DNA helicaseAsymmetry of DNA replication fork progression in Werner's syndromeA unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifsCharacterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseasesWerner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distributionNucleolar localization of the Werner syndrome protein in human cells
P2860
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P2860
description
1996 nî lūn-bûn
@nan
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Positional cloning of the Werner's syndrome gene
@ast
Positional cloning of the Werner's syndrome gene
@en
type
label
Positional cloning of the Werner's syndrome gene
@ast
Positional cloning of the Werner's syndrome gene
@en
prefLabel
Positional cloning of the Werner's syndrome gene
@ast
Positional cloning of the Werner's syndrome gene
@en
P2093
P3181
P1433
P1476
Positional cloning of the Werner's syndrome gene
@en
P2093
Matthews S
Mulligan J
P304
P3181
P356
10.1126/SCIENCE.272.5259.258
P407
P577
1996-04-12T00:00:00Z