MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks - Wikidata - awgldk - TriplyDB

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

http://www.wikidata.org/entity/Q37234327

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XRCC4's interaction with XLF is required for coding (but not signal) end joining Snaps and mends: DNA breaks and chromosomal translocations The response to and repair of RAG-mediated DNA double-strand breaks Role of non-homologous end joining in V(D)J recombination ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination Role of mammalian Mre11 in classical and alternative nonhomologous end joining Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.Autophosphorylation and ATM activation: additional sites add to the complexity.Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination Origin of chromosomal translocations in lymphoid cancer.Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications.Telomeres and immunological diseases of aging Epigenetic regulation of antigen receptor gene rearrangement XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.The RAG2 C terminus suppresses genomic instability and lymphomagenesis.Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinase Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes Lymphocyte development: integration of DNA damage response signaling.Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.Multiple functions of MRN in end-joining pathways during isotype class switching The mre11 complex and the response to dysfunctional telomeres.Increase in double-stranded DNA break-related foci in early-stage thymocytes of aged mice.The MRE11 complex: starting from the ends.Primary immunodeficiencies associated with DNA-repair disorders.DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome.Repair of double-strand breaks by end joining.The biogenesis of chromosome translocations.Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation.

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MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

http://www.wikidata.org/entity/Q37234327

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 16 February 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

@en

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

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type

label

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

@en

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

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prefLabel

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

@en

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

@nl

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Journal of Experimental Medicine

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MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

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Baeck-Seung Lee

http://www.w3.org/2001/XMLSchema#string

Barry P Sleckman

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Beth A Helmink

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Craig H Bassing

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Girdhar G Sharma

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Jeffrey J Bednarski

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Laura M Walker

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Tej K Pandita

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Wan-Ling Lee

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P2860

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Interplay between human DNA repair proteins at a unique double-strand break in vivo

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing.

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

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669-679

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scholarly article

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10.1084/JEM.20081326

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3

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206

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Andrea L. Bredemeyer

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2009-02-16T00:00:00Z

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24019455

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19221393

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2699138

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