A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover - Wikidata - awgldk - TriplyDB

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

http://www.wikidata.org/entity/Q37234369

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SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis.SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5 Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites Quantitative analysis of lipid droplet fusion: inefficient steady state fusion but rapid stimulation by chemical fusogens Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling Spartin recruits PKC-ζ via the PKC-ζ-interacting proteins ZIP1 and ZIP3 to lipid droplets GRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions Caveolin-1 induces formation of membrane tubules that sense actomyosin tension and are inhibited by polymerase I and transcript release factor/cavin-1.Developmental and degenerative features in a complicated spastic paraplegia.Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets.Novel Homozygous Missense Mutation in SPG20 Gene Results in Troyer Syndrome Associated with Mitochondrial Cytochrome c Oxidase Deficiency.Regulation of lipid droplet turnover by ubiquitin ligases.Lipid droplets: size matters.A Luciferase-fragment Complementation Assay to Detect Lipid Droplet-associated Protein-Protein Interactions.Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region Not just fat: the structure and function of the lipid droplet.A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis.Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains Network analyses reveal novel aspects of ALS pathogenesis Spastin binds to lipid droplets and affects lipid metabolism.Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets Protein monoubiquitylation: targets and diverse functions Extracellular purines promote the differentiation of human bone marrow-derived mesenchymal stem cells to the osteogenic and adipogenic lineages.Lipid droplets and cellular lipid metabolism.Mutations in phospholipase DDHD2 cause autosomal recessive hereditary spastic paraplegia (SPG54).Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization.Hereditary spastic paraplegias: membrane traffic and the motor pathway.WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.Cellular pathways of hereditary spastic paraplegia.Expanding roles for lipid droplets.Different expression levels of spartin cause broad spectrum of cellular consequences in human neuroblastoma cells.Target acquired: Selective autophagy in cardiometabolic disease.Alleviation of seipinopathy-related ER stress by triglyceride storage.Establishing the lipid droplet proteome: Mechanisms of lipid droplet protein targeting and degradation.Reticulon-like-1, the Drosophila orthologue of the hereditary spastic paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons.E3 ubiquitin ligase E6AP negatively regulates adipogenesis by downregulating proadipogenic factor C/EBPalpha.Detection of SPG20 gene promoter-methylated DNA, as a novel epigenetic biomarker, in plasma for colorectal cancer diagnosis using the MethyLight method.Loss of ALDH18A1 function is associated with a cellular lipid droplet phenotype suggesting a link between autosomal recessive cutis laxa type 3A and Warburg Micro syndrome.

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A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

http://www.wikidata.org/entity/Q37234369

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on March 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

@en

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.

@nl

type

label

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

@en

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.

@nl

prefLabel

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

@en

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.

@nl

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Journal of Cell Biology

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A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

@en

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Mina Yassaee

http://www.w3.org/2001/XMLSchema#string

Paul D Bieniasz

http://www.w3.org/2001/XMLSchema#string

Scott W Eastman

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

The protein network of HIV budding

ESCRT-III recognition by VPS4 ATPases

The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4

Cidea is associated with lipid droplets and insulin sensitivity in humans

Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A.

The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation

ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells

Role of ESCRT-I in retroviral budding

Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1

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881-894

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scholarly article

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10.1083/JCB.200808041

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6

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184

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2009-03-01T00:00:00Z

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24220913

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19307600

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2699154

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