Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
about
RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradationEstablishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate ProteinsParkin promotes degradation of the mitochondrial pro-apoptotic ARTS proteinEzrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activityHECT E3s and human disease.Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTSSmad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.p53 post-translational modification: deregulated in tumorigenesisUbiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.Making sense of ubiquitin ligases that regulate p53.The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegansA Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts.Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer.The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts.Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma.Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation.Coping with stress: multiple ways to activate p53.p53 regulation upon genotoxic stress: intricacies and complexities.A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnoverControl of p53 multimerization by Ubc13 is JNK-regulatedThe multiple levels of regulation by p53 ubiquitination.Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia.Regulation of human MutYH DNA glycosylase by the E3 ubiquitin ligase mule.Regulation of p53--insights into a complex process.p53-family proteins and their regulators: hubs and spokes in tumor suppression.p53 regulation by ubiquitin.WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.Ubiquitination and the Ubiquitin-Proteasome System as regulators of transcription and transcription factors in epithelial mesenchymal transition of cancer.A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors.Ubiquitination involved enzymes and cancer.Regulation of E3 ubiquitin ligase-1 (WWP1) by microRNA-452 inhibits cancer cell migration and invasion in prostate cancer.Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 ComplexFATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage.miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation.The cyclin-dependent kinase activator, Spy1A, is targeted for degradation by the ubiquitin ligase NEDD4.WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis.
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P2860
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
@ast
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
@en
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
@nl
type
label
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
@ast
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
@en
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
@nl
prefLabel
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
@ast
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
@en
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
@nl
P2860
P3181
P356
P1433
P1476
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
@en
P2093
P2860
P2888
P304
P3181
P356
10.1038/SJ.ONC.1209924
P407
P50
P577
2006-08-21T00:00:00Z
P5875
P6179
1004547742