The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL).
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Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcriptionFlavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growthLow VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma.YueF overexpression inhibits cell proliferation partly through p21 upregulation in renal cell carcinoma.Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms.Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1.pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases.VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1.Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3.Antitumor activity of irradiated riboflavin on human renal carcinoma cell line 786-O.Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression.Adding structural information to the von Hippel-Lindau (VHL) tumor suppressor interaction network.Identification and in silico analysis of novel von Hippel-Lindau (VHL) gene variants from a large population.
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The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL).
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The von Hippel-Lindau protein ...... i through stabilization of BIM
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The von Hippel-Lindau protein ...... ough stabilization of BIM(EL).
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type
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The von Hippel-Lindau protein ...... i through stabilization of BIM
@nl
The von Hippel-Lindau protein ...... ough stabilization of BIM(EL).
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The von Hippel-Lindau protein ...... i through stabilization of BIM
@nl
The von Hippel-Lindau protein ...... ough stabilization of BIM(EL).
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The von Hippel-Lindau protein ...... ough stabilization of BIM(EL).
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10.1038/ONC.2009.35
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2009-03-23T00:00:00Z
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1044567305