Transfer and expression of the human multiple drug resistance gene into live mice
about
Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapyAn efficient vector system to modify cells geneticallyImproved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells.Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectorsChoroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma -chain and multidrug resistance (MDR1) transgenes in canine bone marrow.Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors.Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo.Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs.Molecular imaging of gene expression and protein function in vivo with PET and SPECT.Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells.Gene therapy with drug resistance genes.Survival of the fittest: in vivo selection and stem cell gene therapyRole of efflux pumps and metabolising enzymes in drug delivery.Collection of circulating progenitor cells after epirubicin, paclitaxel and filgrastim in patients with metastatic breast cancer.Developmental-stage-specific expression and regulation of an amphotropic retroviral receptor in hematopoietic cellsIn vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.Chemoprotection effect of multidrug resistance 1 (MDR1) gene transfer to hematopoietic progenitor cells and engrafted in mice with cancer allows intensified chemotherapy.Gene transfer-mediated generation of drug-resistant hemopoiesis.Gene transfer of drug resistance genes. Implications for cancer therapy.Breast cancer: cell and gene therapy.In vivo model systems in P-glycoprotein-mediated multidrug resistance.Pre-clinical evaluation of an in vitro selection protocol for the enrichment of transduced CD34+ cell-derived human dendritic cells.Methotrexate selection of long-term culture initiating cells following transduction of CD34(+) cells with a retrovirus containing a mutated human dihydrofolate reductase gene.Genetic protection of repopulating hematopoietic cells with an improved MDR1-retrovirus allows administration of intensified chemotherapy following stem cell transplantation in mice.Single cell analysis and selection of living retrovirus vector-corrected mucopolysaccharidosis VII cells using a fluorescence-activated cell sorting-based assay for mammalian beta-glucuronidase enzymatic activity.Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice.Efficient retrovirus-mediated transduction of primitive human peripheral blood progenitor cells in stroma-free suspension culture.In vivo selection of retrovirally transduced hematopoietic stem cells.Retrovirus-mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells.F2A sequence linking MGMT(P140K) and MDR1 in a bicistronic lentiviral vector enables efficient chemoprotection of haematopoietic stem cells.
P2860
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P2860
Transfer and expression of the human multiple drug resistance gene into live mice
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1992
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Transfer and expression of the human multiple drug resistance gene into live mice
@en
Transfer and expression of the human multiple drug resistance gene into live mice.
@nl
type
label
Transfer and expression of the human multiple drug resistance gene into live mice
@en
Transfer and expression of the human multiple drug resistance gene into live mice.
@nl
prefLabel
Transfer and expression of the human multiple drug resistance gene into live mice
@en
Transfer and expression of the human multiple drug resistance gene into live mice.
@nl
P2093
P2860
P356
P1476
Transfer and expression of the human multiple drug resistance gene into live mice
@en
P2093
A Himelstein
C Richardson
E de la Flor-Weiss
M Gottesman
P2860
P304
P356
10.1073/PNAS.89.20.9676
P407
P577
1992-10-01T00:00:00Z